This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Thomas R. Kosten, MD; Charles M. Morgan, MD; Jean Falcione, MA; Richard S. Schottenfeld, MD

Arch Gen Psychiatry. 1992;49(11):894-898.

Abstract
• In a double-blind, placebo-controlled 12-week randomized clinical trial, we compared amantadine hydrochloride (300 mg/d; n=33), desipramine hydrochloride (150 mg/d; n=30), and placebo (n=31) in the treatment of cocaineabusing methadone-maintained patients. Treatment retention and medication compliance were excellent, with more than 75% of the patients completing the full 12-week trial. Although reported cocaine abuse was significantly lower in the medicated groups compared with the placebo group at week 4, this difference became nonsignificant at week 8, and no difference was found in cocaine-free urine samples. Future studies of amantadine and desipramine treatment in these patients should consider alternatives to methadone hydrochloride, such as buprenorphine hydrochloride, and the selection of more homogeneous patient subgroups, such as depressed cocaine abusers.

Author Affiliations
From the Substance Abuse Treatment Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, Conn.

Footnotes
Accepted for publication January 9, 1992.

Reprint requests to the Substance Abuse Treatment Unit, 27 Sylvan Ave, New Haven, CT 06519 (Dr Kosten).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

References
APPI Online CME 2007;2007:2-2.
FULL TEXT  

Six-Month Trial of Bupropion With Contingency Management for Cocaine Dependence in a Methadone-Maintained Population
Poling et al.
Arch Gen Psychiatry 2006;63:219-228.
ABSTRACT | FULL TEXT  

Evidence-Based Guidelines for the Pharmacological Management of Substance Misuse, Addiction and Comorbidity: Recommendations from the British Association for Psychopharmacology
Lingford-Hughes et al.
J Psychopharmacol 2004;18:293-335.
 

PHARMACOTHERAPY OF ALCOHOLISM: GAPS IN KNOWLEDGE AND OPPORTUNITIES FOR RESEARCH
Kranzler
Alcohol Alcohol 2000;35:537-547.
ABSTRACT | FULL TEXT  

Medications for Alcohol Dependence--New Vistas
Kranzler
JAMA 2000;284:1016-1017.
FULL TEXT  

Desipramine in Opioid-Dependent Cocaine Abusers Maintained on Buprenorphine vs Methadone
Oliveto et al.
Arch Gen Psychiatry 1999;56:812-820.
ABSTRACT | FULL TEXT  

Alcohol & Drug Abuse: Practical Guidelines for the Treatment of Substance Abusers With Adult Attention-Deficit Hyperactivity Disorder
Levin et al.
Psychiatr. Serv. 1999;50:1001-1003.
FULL TEXT  

Old Psychotherapies for Cocaine Dependence Revisited
Carroll
Arch Gen Psychiatry 1999;56:505-506.
FULL TEXT  

Imipramine Treatment of Opiate-Dependent Patients With Depressive Disorders: A Placebo-Controlled Trial
Nunes et al.
Arch Gen Psychiatry 1998;55:153-160.
ABSTRACT | FULL TEXT  

Psychiatric and Substance Use Comorbidity Among Treatment-Seeking Opioid Abusers
Brooner et al.
Arch Gen Psychiatry 1997;54:71-80.
ABSTRACT  

Management of Cocaine Abuse and Dependence
Mendelson and Mello
NEJM 1996;334:965-972.
FULL TEXT  

Imipramine Treatment of Alcoholics With Primary Depression: A Placebo-Controlled Clinical Trial
McGrath et al.
Arch Gen Psychiatry 1996;53:232-240.
ABSTRACT  

Noradrenergic Dysregulation During Discontinuation of Cocaine Use in Addicts
McDougle et al.
Arch Gen Psychiatry 1994;51:713-719.
ABSTRACT  

Psychotherapy and Pharmacotherapy for Ambulatory Cocaine Abusers
Carroll et al.
Arch Gen Psychiatry 1994;51:177-187.
ABSTRACT  

Addiction Medicine
Franklin
JAMA 1993;270:184-185.
ABSTRACT