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Adam Wolkin, MD; Michael Sanfilipo, MS; Alfred P. Wolf, PhD; Burton Angrist, MD; Jonathan D. Brodie, PhD, MD; John Rotrosen, MD

Arch Gen Psychiatry. 1992;49(12):959-965.

Abstract
• Frontal lobe dysfunction is widely suspected to underlie negative symptoms of schizophrenia. This hypothesis is based largely on long-standing observations of the similarities between the effects of frontal lobe lesions and negative symptoms. However, there is little direct evidence specifically for such an association in schizophrenic patients. We measured the relationship between decreased relative prefrontal cortex glucose metabolism (hypofrontality) using positron emission tomography and evaluated the severity of negative symptoms in 20 chronic schizophrenics who underwent scanning while not receiving neuroleptic drugs. We found a close relationship between negative symptoms and prefrontal hypometabolism, particularly in the right dorsolateral convexity. This association was regionally specific. Furthermore, there was no evidence that this relationship was an artifact of age, cerebral atrophy, or severity of positive symptoms.

Author Affiliations
From the Department of Psychiatry, New York University Medical Center, New York (Drs Wolkin, Angrist, Brodie, and Rotrosen); the Psychiatry Service, New York Veterans Administration Medical Center, New York (Drs Wolkin, Angrist, and Rotrosen and Mr Sanfilipo); and the Chemistry Department, Brookhaven National Laboratory, Upton, NY (Dr Wolf).

Footnotes
Accepted for publication January 30, 1992.

Reprint requests to the New York VA Medical Center (116A), 423 E 23rd St, New York, NY 10010 (Dr Wolkin).

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