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Low Serotonin and Dopamine Metabolite Concentrations in Cerebrospinal Fluid From Bulimic Patients With Frequent Binge Episodes
David C. Jimerson, MD;
Michael D. Lesem, MD;
Walter H. Kaye, MD;
Timothy D. Brewerton, MD
Arch Gen Psychiatry. 1992;49(2):132-138.
Abstract
• Cerebrospinal fluid neurotransmitter metabolite levels were studied to assess whether measures of central serotonin, dopamine, or norepinephrine function are associated with severity of abnormal eating patterns in patients with bulimia nervosa. In comparison with healthy controls (N =17), hospitalized bulimic patients with a history of binge eating more frequently than twice daily (N = 11) had significantly lower CSF concentrations of 5-hydroxyindoleacetic acid and homovanillic acid. For the total patient group (N = 29), levels of both metabolites were significantly inversely correlated with binge frequency. On the basis of preclinical studies, these results were examined in the context of speculative models in which low central serotonin function might contribute to blunted satiety responses in bulimic patients, while low central dopamine activity might play a role in abnormal hedonic responses to food.
Author Affiliations
From the Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Md. Dr Jimerson is now with the Department of Psychiatry, Beth Israel Hospital, and Harvard Medical School, Boston, Mass. Dr Lesem is now with the Department of Psychiatry, University of Texas Medical School, Houston. Dr Kaye is now with the Department of Psychiatry, University of Pittsburgh (Pa). Dr Brewerton is now with the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston.
Footnotes
Accepted for publication June 17, 1991.
Presented in part at the Sixth International Catecholamine Symposium, Jerusalem, Israel, June 18,1987; the annual meeting of the American Psychiatric Association, Montreal, Canada, May 11,1988; and the XVI Congress, Collegium Internationale Neuro-Psychopharmacologicum, Munich, Germany, August 19, 1988.
Reprint requests to Department of Psychiatry, Beth Israel Hospital, 330 Brookline Ave, Boston, MA 02215 (Dr Jimerson).
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