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Relationship to Positive/Negative Symptoms and Prior Neuroleptic Treatment

Rajiv Tandon, MD; James E. Shipley, MD; Stephan Taylor, MD; John F. Greden, MD; Alan Eiser, PhD; John DeQuardo, MD; JoAnn Goodson, RN

Arch Gen Psychiatry. 1992;49(3):185-194.

Abstract
• Polysomnographic abnormalities in schizophrenia are not well characterized and their associations with schizophrenic symptomatology have not been adequately assessed. To address these issues, we recorded electroencephalographic sleep in 20 drug-naive schizophrenics, 20 drugfree but previously medicated schizophrenics, and 15 normal controls. Drug-naive and previously medicated patients had significantly greater impairment of sleep continuity and shorter rapid eye movement latency when compared with controls. In the previously medicated group, findings were significantly influenced by duration of drugfree status. Rapid eye movement latency was inversely correlated with the severity of negative symptoms (r= -$.52) but was unrelated to depressive symptoms. Slow-wave sleep did not differ between schizophrenic patients and normal controls and was unrelated to any clinical parameter. Mechanisms underlying the observed associations between rapid eye movement sleep abnormalities and negative symptoms in the acute phase of schizophrenic illness need to be explored.

Author Affiliations
From the Schizophrenia Program and Sleep Diagnostic and Research Program, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor.

Footnotes
Accepted for publication April 24, 1991.

Read in part at the 29th annual meeting of the American College of Neuropsychopharmacology, San Juan, Puerto Rico, December 10, 1990.

Reprint requests to Schizophrenia Program, University of Michigan Medical Center, UH-9C-9150, Ann Arbor, MI 48109-0120 (Dr Tandon).

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