A Longitudinal Twin Study of 1-Year Prevalence of Major Depression in Women
Kenneth S. Kendler, MD;
Michael C. Neale, PhD;
Ronald C. Kessler, PhD;
Andrew C. Heath, DPhil;
Lindon J. Eaves, PhD, DSc
Arch Gen Psychiatry. 1993;50(11):843-852.
Abstract
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Objectives
This study seeks to clarify the etiologic importance and temporal stability of the genetic and environmental risk factors for 1-year prevalence of major depression (1YP-MD) in women.
Design
One-year prevalence of major depression was personally assessed, using DSM-III-R criteria, at two time points a minimum of 1 year apart.
Participants
Both members of 938 adult femalefemale twin pairs ascertained from the population-based Virginia Twin Registry.
Results
The correlation in liability to 1YP-MD was much greater in monozygotic (MZ) than in dizygotic (DZ) twins at time 1 alone, time 2 alone, or at either time 1 or time 2. Model fitting suggested that the liability to 1YP-MD was due to additive genes and individual specific envi- ronment with a heritability of 41% to 46% and was not biased by violations of the equal environment assumption. Jointly analyzing both times of assessment using a longitudinal twin model suggested that, over a 1-year period, genetic effects on the liability to 1YP-MD were entirely stable, while environmental effects were entirely occasion specific.
Conclusions
These results suggest that (1) genetic factors play a moderate etiologic role in the 1YP-MD, (2) the temporal stability of the liability to major depression in adult women is largely or entirely genetic in origin, and (3) environmental factors play a significant role in the etiology of major depression, but their effects are generally transitory and do not result in enduring changes in the liability to illness.
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