This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Abby J. Fyer, MD; Salvatore Mannuzza, PhD; Tim F. Chapman, MPhil; Michael R. Liebowitz, MD; Donald F. Klein, MD

Arch Gen Psychiatry. 1993;50(4):286-293.

Abstract
• Risks for DSM-III-R anxiety and affective disorders and "subdisorder" (nonimpairing) irrational social fears, among directly interviewed first-degree relatives (n=83) of probands who met criteria for social phobia but for no other lifetime anxiety disorder diagnosis, were contrasted to risks for disorder among similarly evaluated relatives (n=231) of never mentally ill controls. Relatives of social phobia probands had a significantly increased risk for social phobia (16% vs 5%, relative risk=3.12) but not for other anxiety disorders. These results suggest a familial contribution to the development of some cases of social phobia. The specificity of the pattern of intergenerational transmission is consistent with the current nosologic distinction between social phobia and other anxiety disorders.

Author Affiliations
From the Anxiety Disorders Clinic, Department of Therapeutics, New York State Psychiatric Institute (Drs Fyer, Mannuzza, Liebowitz, and Klein and Mr Chapman) and the Department of Psychiatry, Columbia University College of Physicians and Surgeons (Drs Fyer, Mannuzza, Klein, and Liebowitz), New York, NY.

Footnotes
Accepted for publication December 23, 1991.

Reprint requests to New York State Psychiatric Institute, 722 W 168th St, New York, NY 10032 (Dr Fyer).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Alcohol Dependence and Anxiety Disorders: What Is the Relationship?
Schuckit and Hesselbrock
Focus 2004;2:440-453.
ABSTRACT | FULL TEXT  

From Adaptive Emotion to Dysfunction: An Attachment Perspective on Social Anxiety Disorder
Vertue
Pers Soc Psychol Rev 2003;7:170-191.
ABSTRACT  

Family Study of Affective Spectrum Disorder
Hudson et al.
Arch Gen Psychiatry 2003;60:170-177.
ABSTRACT | FULL TEXT  

Neurobiological Mechanisms of Social Anxiety Disorder
Mathew et al.
Am. J. Psychiatry 2001;158:1558-1567.
ABSTRACT | FULL TEXT  

A Review and Meta-Analysis of the Genetic Epidemiology of Anxiety Disorders
Hettema et al.
Am. J. Psychiatry 2001;158:1568-1578.
ABSTRACT | FULL TEXT  

The Genetic Epidemiology of Irrational Fears and Phobias in Men
Kendler et al.
Arch Gen Psychiatry 2001;58:257-265.
ABSTRACT | FULL TEXT  

Patterns of Psychopathology and Dysfunction in High-Risk Children of Parents With Panic Disorder and Major Depression
Biederman et al.
Am. J. Psychiatry 2001;158:49-57.
ABSTRACT | FULL TEXT  

Parental Psychopathology, Parenting Styles, and the Risk of Social Phobia in Offspring: A Prospective-Longitudinal Community Study
Lieb et al.
Arch Gen Psychiatry 2000;57:859-866.
ABSTRACT | FULL TEXT  

The Origins of Social Phobia
Hudson and Rapee
Behav Modif 2000;24:102-129.
ABSTRACT  

Panic and Phobic Anxiety: Defining Phenotypes for Genetic Studies
Smoller and Tsuang
Am. J. Psychiatry 1998;155:1152-1162.
ABSTRACT | FULL TEXT  

A Direct-Interview Family Study of Generalized Social Phobia
Stein et al.
Am. J. Psychiatry 1998;155:90-97.
ABSTRACT | FULL TEXT  

Specificity in Familial Aggregation of Phobic Disorders
Fyer et al.
Arch Gen Psychiatry 1995;52:564-573.
ABSTRACT  

Is the Comorbidity Between Social Phobia and Panic Disorder Due to Familial Cotransmission or Other Factors?
Horwath et al.
Arch Gen Psychiatry 1995;52:574-582.
ABSTRACT  

Generalized Social Phobia: Reliability and Validity
Mannuzza et al.
Arch Gen Psychiatry 1995;52:230-237.
ABSTRACT  

Psychiatric Disorders in Relatives of Probands With Panic Disorder and/or Major Depression
Goldstein et al.
Arch Gen Psychiatry 1994;51:383-394.
ABSTRACT