You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


Advertisement

ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | RSS | Access Rights | Sign In


  Vol. 52 No. 2, February 1995 TABLE OF CONTENTS
  Online Only
 •  Online First Table of
Contents
  News and Views
 •Online Features
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on Web of Science (322)
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Delicious Add to Digg Add to Facebook Add to Reddit Add to Technorati Add to Twitter What's this?

Depression in Patients With Cancer

Diagnosis, Biology, and Treatment

J. Stephen McDaniel, MD; Dominique L. Musselman, MD; Maryfrances R. Porter; Deborah A. Reed, RN, MSN; Charles B. Nemeroff, MD, PhD
From the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Ga.

Arch Gen Psychiatry. 1995;52(2):89-99.


Abstract



This article reviews the challenge of diagnosing depression in patients with cancer. Major depression and depressive symptoms, although commonly encountered in medical populations, are frequently underdiagnosed and undertreated. This is especially true for patients with cancer in whom the diagnosis of major depression is clouded by neurovegetative symptoms that may be secondary to either cancer or depression. Well-established biological markers for major depression are proposed as diagnostic adjuncts in patients with cancer. Studies using biological markers in depressed patients with and without cancer are reviewed, and the implications of diminished immune function in depressed patients with cancer are discussed. The limited database on treatment of depression in patients with cancer also is reviewed. Treatment of depression in these patients improves their dysphoria and other signs and symptoms of depression, improves quality of life, and may improve immune function and survival time. Guidelines for future research are proposed.




Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Delicious Delicious   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Role of nuclear factor-{kappa}B-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents
Gupta et al.
Exp Biol Med 2011;236:658-671.
ABSTRACT | FULL TEXT  

Depression, Anxiety and General Psychopathology in Breast Cancer Patients: A Cross-sectional Control Study
FAFOUTI et al.
In Vivo 2010;24:803-810.
ABSTRACT | FULL TEXT  

Association of IL-6, Hypothalamus-Pituitary-Adrenal Axis Function, and Depression in Patients With Cancer
Jehn et al.
Integr Cancer Ther 2010;9:270-275.
ABSTRACT  

Loss of Resources as Mediators between Interpersonal Trauma and Traumatic and Depressive Symptoms among Women with Cancer
Banou et al.
J Health Psychol 2009;14:200-214.
ABSTRACT  

Behavioral Health Services for Women Who Have Breast Cancer
Azzone et al.
JCO 2009;27:706-712.
ABSTRACT | FULL TEXT  

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis
Howren et al.
Psychosom. Med. 2009;71:171-186.
ABSTRACT | FULL TEXT  

Patient-Perceived Barriers to the Psychological Care of Japanese Patients with Lung Cancer
Endo et al.
Jpn J Clin Oncol 2008;38:653-660.
ABSTRACT | FULL TEXT  

A Randomized, Placebo-Controlled Trial of Citalopram for the Prevention of Major Depression During Treatment for Head and Neck Cancer
Lydiatt et al.
Arch Otolaryngol Head Neck Surg 2008;134:528-535.
ABSTRACT | FULL TEXT  

Evaluation and characterization of generalized anxiety and depression in patients with primary brain tumors
Arnold et al.
Neuro Oncol 2008;10:171-181.
ABSTRACT | FULL TEXT  

Neuroendocrine-Immune Mechanisms of Behavioral Comorbidities in Patients With Cancer
Miller et al.
JCO 2008;26:971-982.
ABSTRACT | FULL TEXT  

Comorbid Depression in Adult Oncology
Jackson and Jackson
Journal of Pharmacy Practice 2007;20:360-367.
ABSTRACT  

Cancer-Related Fatigue: The Scale of the Problem
Hofman et al.
The Oncologist 2007;12:4-10.
ABSTRACT | FULL TEXT  

Alcoholism, depression, and abnormal cognition in head and neck cancer: A pilot study
McCaffrey et al.
Otolaryngol Head Neck Surg 2007;136:92-97.
ABSTRACT | FULL TEXT  

The Moderating Effects of Anxiety and Breast Cancer Locus of Control on Depression
Naus et al.
J Health Psychol 2005;10:687-694.
ABSTRACT  

Role of Depression As a Predictor of Mortality Among Cancer Patients After Stem-Cell Transplantation
Prieto et al.
JCO 2005;23:6063-6071.
ABSTRACT | FULL TEXT  

Lack of Attenuation in the Antitumor Effect of Tamoxifen by Chronic CYP Isoform Inhibition
Lehmann et al.
J Clin Pharmacol 2004;44:861-865.
ABSTRACT | FULL TEXT  

Prevalence of Depression in Patients With Cancer
Massie
J Natl Cancer Inst Monogr 2004;2004:57-71.
ABSTRACT | FULL TEXT  

Depression and Pain Comorbidity: A Literature Review
Bair et al.
Arch Intern Med 2003;163:2433-2445.
ABSTRACT | FULL TEXT  

Clinical Factors Associated with Suicidality in Cancer Patients
Akechi et al.
Jpn J Clin Oncol 2002;32:506-511.
ABSTRACT | FULL TEXT  

Psychiatric Morbidity and Impact on Hospital Length of Stay Among Hematologic Cancer Patients Receiving Stem-Cell Transplantation
Prieto et al.
JCO 2002;20:1907-1917.
ABSTRACT | FULL TEXT  

Palliative Uses of Methylphenidate in Patients With Cancer: A Review
Rozans et al.
JCO 2002;20:335-339.
ABSTRACT | FULL TEXT  

Workplace Experiences of Individuals Who Are HIV+ and Individuals with Cancer
Fesko
Rehabil Couns Bull 2001;45:2-11.
ABSTRACT  

Cancer-Related Fatigue: Prevalence of Proposed Diagnostic Criteria in a United States Sample of Cancer Survivors
Cella et al.
JCO 2001;19:3385-3391.
ABSTRACT | FULL TEXT  

Diurnal Cortisol Rhythm as a Predictor of Breast Cancer Survival
Sephton et al.
JNCI J Natl Cancer Inst 2000;92:994-1000.
ABSTRACT | FULL TEXT  

Suicidal Ideation in Cancer Patients with Major Depression
Akechi et al.
Jpn J Clin Oncol 2000;30:221-224.
ABSTRACT | FULL TEXT  

Social Support and Salivary Cortisol in Women With Metastatic Breast Cancer
Turner-Cobb et al.
Psychosom. Med. 2000;62:337-345.
ABSTRACT | FULL TEXT  

Depression in Patients With Lung Cancer: Prevalence and Risk Factors Derived From Quality-of-Life Data
Hopwood and Stephens
JCO 2000;18:893-893.
ABSTRACT | FULL TEXT  

Coping, Distress, and Survival Among Patients With Lung Cancer
Faller et al.
Arch Gen Psychiatry 1999;56:756-762.
ABSTRACT | FULL TEXT  

Screening for psychiatric illness in the palliative care inpatient setting: a comparison between the Hospital Anxiety and Depression Scale and the General Health Questionnaire-12
Le Fevre et al.
Palliat Med 1999;13:399-407.
ABSTRACT  

Psychopathological and emotional deficits in myotonic dystrophy
Bungener et al.
J. Neurol. Neurosurg. Psychiatry 1998;65:353-356.
ABSTRACT | FULL TEXT  

Screening for Psychological Distress in Japanese Cancer Patients
Kugaya et al.
Jpn J Clin Oncol 1998;28:333-338.
ABSTRACT | FULL TEXT  

Assisted Suicide and Euthanasia: What about the Clinical Issues?
Kelly and Varghese
Aust N Z J Psychiatry 1996;30:3-8.
ABSTRACT  

The Role of Methylphenidate in Psychiatry
Klein and Wender
Arch Gen Psychiatry 1995;52:429-433.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | PHYSICIAN JOBS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1995 American Medical Association. All Rights Reserved.