This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Diagnosis, Biology, and Treatment

J. Stephen McDaniel, MD; Dominique L. Musselman, MD; Maryfrances R. Porter; Deborah A. Reed, RN, MSN; Charles B. Nemeroff, MD, PhD
From the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Ga.

Arch Gen Psychiatry. 1995;52(2):89-99.

Abstract
This article reviews the challenge of diagnosing depression in patients with cancer. Major depression and depressive symptoms, although commonly encountered in medical populations, are frequently underdiagnosed and undertreated. This is especially true for patients with cancer in whom the diagnosis of major depression is clouded by neurovegetative symptoms that may be secondary to either cancer or depression. Well-established biological markers for major depression are proposed as diagnostic adjuncts in patients with cancer. Studies using biological markers in depressed patients with and without cancer are reviewed, and the implications of diminished immune function in depressed patients with cancer are discussed. The limited database on treatment of depression in patients with cancer also is reviewed. Treatment of depression in these patients improves their dysphoria and other signs and symptoms of depression, improves quality of life, and may improve immune function and survival time. Guidelines for future research are proposed.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Loss of Resources as Mediators between Interpersonal Trauma and Traumatic and Depressive Symptoms among Women with Cancer
Banou et al.
J Health Psychol 2009;14:200-214.
ABSTRACT  

Behavioral Health Services for Women Who Have Breast Cancer
Azzone et al.
JCO 2009;27:706-712.
ABSTRACT | FULL TEXT  

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis
Howren et al.
Psychosom. Med. 2009;71:171-186.
ABSTRACT | FULL TEXT  

Patient-Perceived Barriers to the Psychological Care of Japanese Patients with Lung Cancer
Endo et al.
Jpn J Clin Oncol 2008;38:653-660.
ABSTRACT | FULL TEXT  

Cancer Fatigue: A Neurobiological Review for Psychiatrists
Levy
Psychosomatics 2008;49:283-291.
ABSTRACT | FULL TEXT  

A Randomized, Placebo-Controlled Trial of Citalopram for the Prevention of Major Depression During Treatment for Head and Neck Cancer
Lydiatt et al.
Arch Otolaryngol Head Neck Surg 2008;134:528-535.
ABSTRACT | FULL TEXT  

Evaluation and characterization of generalized anxiety and depression in patients with primary brain tumors
Arnold et al.
Neuro Oncol Duke 2008;10:171-181.
ABSTRACT | FULL TEXT  

Neuroendocrine-Immune Mechanisms of Behavioral Comorbidities in Patients With Cancer
Miller et al.
JCO 2008;26:971-982.
ABSTRACT | FULL TEXT  

Comorbid Depression in Adult Oncology
Jackson and Jackson
Journal of Pharmacy Practice 2007;20:360-367.
ABSTRACT  

Tamoxifen Treatment and New-Onset Depression in Breast Cancer Patients
Lee et al.
Psychosomatics 2007;48:205-210.
ABSTRACT | FULL TEXT  

Cancer-Related Fatigue: The Scale of the Problem
Hofman et al.
The Oncologist 2007;12:4-10.
ABSTRACT | FULL TEXT  

Measuring Somatic Symptoms With the CES-D to Assess Depression in Cancer Patients After Treatment: Comparison Among Patients With Oral/Oropharyngeal, Gynecological, Colorectal, and Breast Cancer
van Wilgen et al.
Psychosomatics 2006;47:465-470.
ABSTRACT | FULL TEXT  

The Diagnosis of Major Depression in Patients With Cancer: A Comparative Approach
Guo et al.
Psychosomatics 2006;47:376-384.
ABSTRACT | FULL TEXT  

The Moderating Effects of Anxiety and Breast Cancer Locus of Control on Depression
Naus et al.
J Health Psychol 2005;10:687-694.
ABSTRACT  

Role of Depression As a Predictor of Mortality Among Cancer Patients After Stem-Cell Transplantation
Prieto et al.
JCO 2005;23:6063-6071.
ABSTRACT | FULL TEXT  

Lack of Attenuation in the Antitumor Effect of Tamoxifen by Chronic CYP Isoform Inhibition
Lehmann et al.
J Clin Pharmacol 2004;44:861-865.
ABSTRACT | FULL TEXT  

Prevalence of Depression in Patients With Cancer
Massie
J Natl Cancer Inst Monogr 2004;2004:57-71.
ABSTRACT | FULL TEXT  

Depression and Pain Comorbidity: A Literature Review
Bair et al.
Arch Intern Med 2003;163:2433-2445.
ABSTRACT | FULL TEXT  

Somatic Symptoms for Diagnosing Major Depression in Cancer Patients
Akechi et al.
Psychosomatics 2003;44:244-248.
ABSTRACT | FULL TEXT  

Depression as a Prognostic Factor for Breast Cancer Mortality
Hjerl et al.
Psychosomatics 2003;44:24-30.
ABSTRACT | FULL TEXT  

Clinical Factors Associated with Suicidality in Cancer Patients
Akechi et al.
Jpn J Clin Oncol 2002;32:506-511.
ABSTRACT | FULL TEXT  

Psychiatric Morbidity and Impact on Hospital Length of Stay Among Hematologic Cancer Patients Receiving Stem-Cell Transplantation
Prieto et al.
JCO 2002;20:1907-1917.
ABSTRACT | FULL TEXT  

Palliative Uses of Methylphenidate in Patients With Cancer: A Review
Rozans et al.
JCO 2002;20:335-339.
ABSTRACT | FULL TEXT  

Workplace Experiences of Individuals Who Are HIV+ and Individuals with Cancer
Fesko
Rehabil Couns Bull 2001;45:2-11.
ABSTRACT  

Higher Than Normal Plasma Interleukin-6 Concentrations in Cancer Patients With Depression: Preliminary Findings
Musselman et al.
Am. J. Psychiatry 2001;158:1252-1257.
ABSTRACT | FULL TEXT  

Cancer-Related Fatigue: Prevalence of Proposed Diagnostic Criteria in a United States Sample of Cancer Survivors
Cella et al.
JCO 2001;19:3385-3391.
ABSTRACT | FULL TEXT  

The Reappearance of Depression in an Elderly Man: What Lurks Behind It?
Ashley et al.
Am. J. Psychiatry 2000;157:1943-1947.
FULL TEXT  

Diurnal Cortisol Rhythm as a Predictor of Breast Cancer Survival
Sephton et al.
JNCI J Natl Cancer Inst 2000;92:994-1000.
ABSTRACT | FULL TEXT  

Suicidal Ideation in Cancer Patients with Major Depression
Akechi et al.
Jpn J Clin Oncol 2000;30:221-224.
ABSTRACT | FULL TEXT  

Social Support and Salivary Cortisol in Women With Metastatic Breast Cancer
Turner-Cobb et al.
Psychosom. Med. 2000;62:337-345.
ABSTRACT | FULL TEXT  

Biopsychosocial Aspects of Prostate Cancer
Kunkel et al.
Psychosomatics 2000;41:85-94.
ABSTRACT | FULL TEXT  

Depression in Patients With Lung Cancer: Prevalence and Risk Factors Derived From Quality-of-Life Data
Hopwood and Stephens
JCO 2000;18:893-893.
ABSTRACT | FULL TEXT  

Coping, Distress, and Survival Among Patients With Lung Cancer
Faller et al.
Arch Gen Psychiatry 1999;56:756-762.
ABSTRACT | FULL TEXT  

Screening for psychiatric illness in the palliative care inpatient setting: a comparison between the Hospital Anxiety and Depression Scale and the General Health Questionnaire-12
Le Fevre et al.
Palliat Med 1999;13:399-407.
ABSTRACT  

Psychopathological and emotional deficits in myotonic dystrophy
Bungener et al.
J. Neurol. Neurosurg. Psychiatry 1998;65:353-356.
ABSTRACT | FULL TEXT  

Psychiatry and Assisted Suicide in the United States
Ganzini and Lee
NEJM 1997;336:1824-1826.
FULL TEXT  

The Role of Methylphenidate in Psychiatry
Klein and Wender
Arch Gen Psychiatry 1995;52:429-433.
ABSTRACT