Efficacy of Methylphenidate for Attention-Deficit Hyperactivity Disorder in Children With Tic Disorder

doi:10.1001/archpsyc.1995.03950180030005

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 52 No. 6, June 1995

Online Only
	•	Online First Table of Contents

Original Articles

•	Online Features

This Article
•	References
•	Full text PDF
•	Correction
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (100)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Efficacy of Methylphenidate for Attention-Deficit Hyperactivity Disorder in Children With Tic Disorder

Kenneth D. Gadow, PhD; Jeffrey Sverd, MD; Joyce Sprafkin, PhD; Edith E. Nolan, PhD; Stacy N. Ezor, MA

Arch Gen Psychiatry. 1995;52(6):444-455.

Abstract

Background
The findings from case reports and patient questionnaire surveyshave been interpreted as indicating that administration of stimulantsis ill-advised for the treatment of attention-deficit hyperactivitydisorder in children with tic disorder.

Methods
Thirty-four prepubertal children with attention-deficit hyperactivitydisorder and tic disorder received placebo and three dosagesof methylphenidate hydrochloride (0.1, 0.3, and 0.5 mg/kg) twicedaily for 2 weeks each, under double-blind conditions. Treatmenteffects were assessed using direct observations of child behaviorin a simulated (clinic-based) classroom and using rating scalescompleted by the parents, teachers, and physician.

Results
Methylphenidate effectively suppressed hyperactive, disruptive,and aggressive behavior. There was no evidence that methylphenidatealtered the severity of tic disorder, but it may have a weakeffect on the frequency of motor (increase) and vocal (decrease)tics.

Conclusion
Methylphenidate appears to be a safe and effective treatmentfor attention-deficit hyperactivity disorder in the majorityof children with comorbid tic disorder.

Author Affiliations

From the Department of Psychiatry and Behavioral Science, State University of New York-Stony Brook (Drs Gadow, Sverd, Sprafkin, and Nolan and Ms Ezor) and Sagamore Children's Psychiatric Center, Office of Mental Health, State of New York, Dix Hills (Dr Sverd).

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Methylphenidate and Comorbid Anxiety Disorder in Children With Both Chronic Multiple Tic Disorder and ADHD
Gadow and Nolan
J Atten Disord 2011;15:246-256.
ABSTRACT

Methylphenidate in Children With Oppositional Defiant Disorder and Both Comorbid Chronic Multiple Tic Disorder and ADHD
Gadow et al.
J Child Neurol 2008;23:981-990.
ABSTRACT

Atomoxetine Versus Stimulants for Treatment of Attention Deficit/Hyperactivity Disorder
Gibson et al.
The Annals of Pharmacotherapy 2006;40:1134-1142.
ABSTRACT | FULL TEXT

A placebo-controlled study of lofexidine in the treatment of children with tic disorders and attention deficit hyperactivity disorder
Niederhofer et al.
J Psychopharmacol 2003;17:113-119.
ABSTRACT

The Utility of a DSM-IV-Referenced Screening Instrument for Attention-Deficit/Hyperactivity Disorder
Sprafkin et al.
Journal of Emotional and Behavioral Disorders 2001;9:182-191.
ABSTRACT

The 4-Year Course of Tic Disorders in Boys With Attention-Deficit/Hyperactivity Disorder
Spencer et al.
Arch Gen Psychiatry 1999;56:842-847.
ABSTRACT | FULL TEXT

Long-term Methylphenidate Therapy in Children With Comorbid Attention-Deficit Hyperactivity Disorder and Chronic Multiple Tic Disorder
Gadow et al.
Arch Gen Psychiatry 1999;56:330-336.
ABSTRACT | FULL TEXT

Stimulants and Tic Disorders: From Dogma to Data
Castellanos
Arch Gen Psychiatry 1999;56:337-338.
FULL TEXT

Stimulant Medication Withdrawal During Long-term Therapy in Children With Comorbid Attention-Deficit Hyperactivity Disorder and Chronic Multiple Tic Disorder
Nolan et al.
Pediatrics 1999;103:730-737.
ABSTRACT | FULL TEXT

New Findings on Methylphenidate in Children and Adults
JWatch Psychiatry 1995;1995:4-4.
FULL TEXT

The Role of Methylphenidate in Psychiatry
Klein and Wender
Arch Gen Psychiatry 1995;52:429-433.
ABSTRACT

| | |