 |
|
Increased Rate of P300 Latency Prolongation With Age in SchizophreniaElectrophysiological Evidence for a Neurodegenerative Process
Brian F. O'Donnell, PhD;
Steven F. Faux, PhD;
Robert W. McCarley, MD;
Matthew O. Kimble;
Dean F. Salisbury, PhD;
Paul G. Nestor, PhD;
Ron Kikinis, MD;
Ferenc A. Jolesz, MD;
Martha E. Shenton, PhD
Arch Gen Psychiatry. 1995;52(7):544-549.
Abstract
| |
Background
The latency of the P300 event-related Potential is prolonged in disorders associated with neural damage and degeneration and also becomes prolonged in the course of neural changes that accompany aging. We tested whether the rate of P300 latency increase with age was greater in male schizophrenic patients than in normal subjects because a steeper slope in schizophrenia would suggest a progressive neurodegenerative Process. We also evaluated a subset of these subjects for changes in brain volumes as determined by magnetic resonance imaging.
Method
The P300 component was elicited during an auditory "oddball" paradigm and was recorded from 47 male patients with chronic schizophrenia whose mean age at onset was 22.4 years and from 47 age-, handedness-, and gender-matched control subjects. The relation of P300 latency and amplitude to age within each group was evaluated using correlation and regression analyses. Brain volumes determined via magnetic resonance imaging were evaluated by quantitative volumetric analyses of images acquired with three-dimensional Fourier transform and double echo-spin echo-pulse sequences. The slope of P300 latency on age was steeper for schizophrenic patients than for normal control subjects at midline frontal and central electrode sites. The slope of N100 latency did not differ, implying that the P300 differences were not likely to be due to peripheral hearing loss or damage affecting the initial stages of neural processing. Posterior superior temporal gyrus gray matter volume determined via magnetic resonance imaging significantly diminished with age on the left side in patients with schizophrenia but not on the right side or in controls; these slopes were not, however, statistically significantly different from each other. These findings provide preliminary evidence that male patients with chronic schizophrenia experience a neurodegenerative process that becomes evident in adulthood and is reflected by the rate of change of P300 latency with age. Whether this process is due to the primary effects of schizophrenia or is secondary to factors associated with schizophrenia's chronic course and treatment remains a question for future investigation.
Results
The slope of P300 latency on age was steeper for schizophrenic patients than for normal control subjects at midline frontal and central electrode sites. The slope of N100 latency did not differ, implying that the P300 differences were not likely to be due to peripheral hearing loss or damage affecting the initial stages of neural processing. Posterior superior temporal gyrus gray matter volume determined via magnetic resonance imaging significantly diminished with age on the left side in patients with schizophrenia but not on the right side or in controls; these slopes were not, however, statistically significantly different from each other.
Conclusions
These findings provide preliminary evidence that male patients with chronic schizophrenia experience a neurodegenerative process that becomes evident in adulthood and is reflected by the rate of change of P300 latency with age. Whether this process is due to the primary effects of schizophrenia or is secondary to factors associated with schizophrenia's chronic course and treatment remains a question for future investigation.
Author Affiliations
From the Departments of Psychiatry (Drs O'Donnell, McCarley, Salisbury, Nestor, and Shenton and Mr Kimble) and Radiology (Drs Kikinis and Jolesz), Harvard Medical School, Boston, Mass; the Brockton (Mass) Veterans Affairs Medical Center (Drs O'Donnell, McCarley, Salisbury, Nestor, and Shenton and Mr Kimble); the Department of Radiology, Magnetic Resonance Imaging Division, Surgical Planning Center, Brigham and Women's Hospital, Boston (Drs Kikinis and Jolesz); and the Department of Psychology, Drake University, Des Moines, Iowa (Dr Faux).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Progressive and Interrelated Functional and Structural Evidence of Post-Onset Brain Reduction in Schizophrenia
Salisbury et al.
Arch Gen Psychiatry 2007;64:521-529.
ABSTRACT
| FULL TEXT
Neurophysiological Endophenotypes of Schizophrenia: The Viability of Selected Candidate Measures
Turetsky et al.
Schizophr Bull 2007;33:69-94.
ABSTRACT
| FULL TEXT
Progressive Decrease of Left Heschl Gyrus and Planum Temporale Gray Matter Volume in First-Episode Schizophrenia: A Longitudinal Magnetic Resonance Imaging Study
Kasai et al.
Arch Gen Psychiatry 2003;60:766-775.
ABSTRACT
| FULL TEXT
Progressive Decrease of Left Superior Temporal Gyrus Gray Matter Volume in Patients With First-Episode Schizophrenia
Kasai et al.
Am. J. Psychiatry 2003;160:156-164.
ABSTRACT
| FULL TEXT
Stability and Course of Neuropsychological Deficits in Schizophrenia
Heaton et al.
Arch Gen Psychiatry 2001;58:24-32.
ABSTRACT
| FULL TEXT
Schizophrenia as a Disorder of Developmentally Reduced Synaptic Connectivity
McGlashan and Hoffman
Arch Gen Psychiatry 2000;57:637-648.
ABSTRACT
| FULL TEXT
Dementia Praecox Lives Up to Its Name
JWatch Psychiatry 1995;1995:3-3.
FULL TEXT
Event-Related Potentials in the Study of Psychiatric Disorders
Pfefferbaum et al.
Arch Gen Psychiatry 1995;52:559-563.
ABSTRACT
|
