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The Contribution of 2-Noradrenergic Mechanisms to Prefrontal Cortical Cognitive Function

Potential Significance for Attention-Deficit Hyperactivity Disorder

Amy F.T. Arnsten, PhD; Jenna C. Steere, MPH; Robert D. Hunt, MD
From the Section of Neurobiology, Yale Medical School, New Haven, Conn (Dr Arnsten and Ms Steere), and the Center for Attention and Hyperactivity Disorders, Nashville, Tenn (Dr Hunt).

Arch Gen Psychiatry. 1996;53(5):448-455.

Abstract
This article aims to review research in nonhuman primates demonstrating that norepinephrine can enhance the cognitive functioning of the prefrontal cortex through actions at 2A-adrenergic receptors postjunctional to noradrenergic terminals. As prefrontal cortex cognitive deficits are prominent in several psychiatric disorders, including attention-deficit hyperactivity disorder, these basic findings may have relevance for the development of novel pharmacotherapies.

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