 |
|
Eye Tracking, Attention, and Schizotypal Symptoms in Nonpsychotic Relatives of Patients With Schizophrenia
Richard S. E. Keefe, PhD;
Jeremy M. Silverman, PhD;
Richard C. Mohs, PhD;
Larry J. Siever, MD;
Philip D. Harvey, PhD;
Lee Friedman, PhD;
Sonia E. Lees Roitman;
Rachel L. DuPre;
Christopher J. Smith;
James Schmeidler, PhD;
Kenneth L. Davis, MD
Arch Gen Psychiatry. 1997;54(2):169-176.
Abstract
| |
Background
Biological relatives of patients with schizophrenia demonstrate an increased prevalence of schizotypal personality disorder symptoms, eye tracking deficits, and attentional disturbances. We investigated whether these hypothesized components of a schizophrenia-related phenotype are associated with one another or are independent in nonpsychotic relatives of patients with schizophrenia.
Methods
Eighty-three nonpsychotic first-degree relatives of 38 patients with schizophrenia and 45 control subjects without a psychiatric diagnosis underwent clinical evaluation, eye tracking evaluation, and the Continuous Performance Test (CPT) of visual attention.
Results
Eye tracking qualitative rating was more powerful than quantitative eye tracking measures or CPT measures in discriminating relatives of patients with schizophrenia from control subjects. Correlations between neurocognitive variables and DSM-III-R schizotypal personality disorder symptom clusters suggested that CPT errors of omission are associated with positive schizotypal symptoms. Eye tracking measures were not significantly correlated with schizotypal symptoms or CPT errors in relatives of patients with schizophrenia.
Conclusions
Eye tracking deficits in the relatives of patients with schizophrenia are unrelated to CPT deficits and schizotypal symptoms. Eye tracking deficits and disturbances in visual attention may be separate components of a schizophrenia-related phenotype and should be considered as independent factors in genetic studies of schizophrenia.
Author Affiliations
From the Department of Psychiatry, Mount Sinai School of Medicine, New York, and the Bronx Veterans Affairs Medical Center, Bronx, NY (Drs Keefe, Silverman, Mohs, Siever, Harvey, Schmeidler, and Davis, Mss Lees Roitman and DuPre, and Mr Smith); and the Laboratory of Biological Psychiatry, Case Western Reserve University, Cleveland, Ohio (Dr Friedman). Dr Keefe is now affiliated with the Department of Psychiatry, Duke University Medical Center, Durham, NC.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Executive Subprocesses in Working Memory: Relationship to Catechol-O-methyltransferase Val158Met Genotype and Schizophrenia
Goldberg et al.
Arch Gen Psychiatry 2003;60:889-896.
ABSTRACT
| FULL TEXT
Deficits in Gain of Smooth Pursuit Eye Movements in Schizophrenia and Affective Disorder Patients and Their Unaffected Relatives
Kathmann et al.
Am. J. Psychiatry 2003;160:696-702.
ABSTRACT
| FULL TEXT
Relative Risk of Attention Deficits in Siblings of Patients With Schizophrenia
Egan et al.
Am. J. Psychiatry 2000;157:1309-1316.
ABSTRACT
| FULL TEXT
Premorbid Speech and Language Impairments in Childhood-Onset Schizophrenia: Association With Risk Factors
Nicolson et al.
Am. J. Psychiatry 2000;157:794-800.
ABSTRACT
| FULL TEXT
Sensory Gating Deficits Assessed by the P50 Event-Related Potential in Subjects With Schizotypal Personality Disorder
Cadenhead et al.
Am. J. Psychiatry 2000;157:55-59.
ABSTRACT
| FULL TEXT
Neural Correlates of Eye Tracking Deficits in First-degree Relatives of Schizophrenic Patients: A Positron Emission Tomography Study
O'Driscoll et al.
Arch Gen Psychiatry 1999;56:1127-1134.
ABSTRACT
| FULL TEXT
Neurobehavioral Deficits at Adolescence in Children at Risk for Schizophrenia: The Jerusalem Infant Development Study
Hans et al.
Arch Gen Psychiatry 1999;56:741-748.
ABSTRACT
| FULL TEXT
Saccadic Eye Movements in Families Multiply Affected With Schizophrenia: The Maudsley Family Study
Crawford et al.
Am. J. Psychiatry 1998;155:1703-1710.
ABSTRACT
| FULL TEXT
Smooth Pursuit Eye Movements to Extraretinal Motion Signals: Deficits in Relatives of Patients With Schizophrenia
Thaker et al.
Arch Gen Psychiatry 1998;55:830-836.
ABSTRACT
| FULL TEXT
Antisaccades and Smooth Pursuit Eye Tracking and Schizotypy
O'Driscoll et al.
Arch Gen Psychiatry 1998;55:837-843.
ABSTRACT
| FULL TEXT
Specific Measures Account for Most of the Variance in Qualitative Ratings of Smooth Pursuit Eye Movements in Schizophrenia
Ross et al.
Arch Gen Psychiatry 1998;55:184-186.
FULL TEXT
|
