 |
|
Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder
J. Douglas Bremner, MD;
Robert B. Innis, MD, PhD;
Chin K. Ng, PhD;
Lawrence H. Staib, PhD;
Ronald M. Salomon, MD;
Richard A. Bronen, MD;
James Duncan, PhD;
Steven M. Southwick, MD;
John H. Krystal, MD;
Dayton Rich;
George Zubal, PhD;
Holley Dey, MD;
Robert Soufer, MD;
Dennis S. Charney, MD
Arch Gen Psychiatry. 1997;54(3):246-254.
Abstract
Background
We have previously reported an increase in symptoms of anxiety in patients with posttraumatic stress disorder (PTSD) following administration of the β2-antagonist yohimbine, which stimulates brain norepinephrine release. Preclinical studies show decreased metabolism in the neocortex and the caudate nucleus with high-dose yohimbine-induced norepinephrine release, but low levels of norepinephrine release result in an increase in metabolism in these areas.
Methods
We used positron emission tomography and fludeoxyglucose F 18 to measure brain metabolism in Vietnam combat veterans with PTSD (n=10) and healthy age-matched control subjects (n=10), following administration of yohimbine (0.4 mg/kg) or placebo in a randomized, double-blind fashion.
Results
Yohimbine resulted in a significant increase in anxiety in the patients with PTSD, but not in healthy subjects. There was a significant difference in brain metabolic response to yohimbine in patients with PTSD compared with healthy subjects in prefrontal, temporal, parietal, and orbitofrontal cortexes. Metabolism tended to decrease in patients with PTSD and increase in healthy subjects following administration of yohimbine.
Conclusion
These findings are consistent with our previous hypothesis of enhanced norepinephrine release in the brain with yohimbine in patients with PTSD.
Author Affiliations
From the Departments of Psychiatry (Drs Bremner, Innis, Salomon, Southwick, Krystal, and Charney) and Diagnostic Radiology (Drs Bremner, Ng, Staib, Bronen, Duncan, Zubal, Dey, and Soufer), Yale University School of Medicine, New Haven, Conn; and the National Center for Posttraumatic Stress Disorder (Drs Bremner, Innis, Southwick, Krystal, and Charney), West Haven Veterans Affairs Medical Center (Drs Bremner, Innis, Ng, Salomon, Southwick, Krystal, Dey, Soufer, and Charney and Mr Rich), and the Yale/Veterans Affairs Positron Emission Tomography Center (Drs Ng, Dey, and Soufer and Mr Rich), West Haven, Conn.
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Resting Metabolic Activity in the Cingulate Cortex and Vulnerability to Posttraumatic Stress Disorder
Shin et al.
Arch Gen Psychiatry 2009;66:1099-1107.
ABSTRACT
| FULL TEXT
Noradrenergic Innervation of the Dorsal Medial Prefrontal Cortex Modulates Hypothalamo-Pituitary-Adrenal Responses to Acute Emotional Stress
Radley et al.
J. Neurosci. 2008;28:5806-5816.
ABSTRACT
| FULL TEXT
Catecholamine and Second Messenger Influences on Prefrontal Cortical Networks of "Representational Knowledge": A Rational Bridge between Genetics and the Symptoms of Mental Illness
Arnsten
Cereb Cortex 2007;17:i6-i15.
ABSTRACT
| FULL TEXT
Differential Effects of 5-HTTLPR Genotypes on the Behavioral and Neural Responses to Tryptophan Depletion in Patients With Major Depression and Controls.
Neumeister et al.
Arch Gen Psychiatry 2006;63:978-986.
ABSTRACT
| FULL TEXT
Neuroimaging findings in post-traumatic stress disorder: Systematic review
HULL
Br. J. Psychiatry 2002;181:102-110.
ABSTRACT
| FULL TEXT
Dysregulation of the Right Brain: A Fundamental Mechanism of Traumatic Attachment and the Psychopathogenesis of Posttraumatic Stress Disorder
Schore
Aust N Z J Psychiatry 2002;36:9-30.
ABSTRACT
| FULL TEXT
The Future of Imaging in Drug Discovery
Schmidt
Journal of Pharmacy Practice 2001;14:427-434.
ABSTRACT
Cerebral Activation in Patients With Irritable Bowel Syndrome and Control Subjects During Rectosigmoid Stimulation
Naliboff et al.
Psychosom. Med. 2001;63:365-375.
ABSTRACT
| FULL TEXT
Relationship Among Plasma Cortisol, Catecholamines, Neuropeptide Y, and Human Performance During Exposure to Uncontrollable Stress
Morgan et al.
Psychosom. Med. 2001;63:412-422.
ABSTRACT
| FULL TEXT
The neurobiology of stress and gastrointestinal disease
MAYER
Gut 2000;47:861-869.
FULL TEXT
Effects of Yohimbine on Cerebral Blood Flow, Symptoms, and Physiological Functions in Humans
Cameron et al.
Psychosom. Med. 2000;62:549-559.
ABSTRACT
| FULL TEXT
Decreased Brain GABAA-Benzodiazepine Receptor Binding in Panic Disorder: Preliminary Results From a Quantitative PET Study
Malizia et al.
Arch Gen Psychiatry 1998;55:715-720.
ABSTRACT
| FULL TEXT
|
