 |
|
Magnetic Source Imaging Evidence of Sex Differences in Cerebral Lateralization in Schizophrenia
Martin Reite, MD;
Jeanelle Sheeder;
Peter Teale, MSEE;
Matthew Adams;
Douglas Richardson;
Jack Simon, MD, PhD;
Richard H. Jones, PhD;
Donald C. Rojas, PhD
Arch Gen Psychiatry. 1997;54(5):433-440.
Abstract
| |
Background
It has been postulated that schizophrenia represents a disorder of anomalous cerebral lateralization. This study is a replication of earlier preliminary findings using a multichannel neuromagnetometer, suggesting altered lateralization in schizophrenia in male subjects, with an extension of the findings to female subjects.
Methods
We used magnetoencephalography-based magnetic source imaging to estimate the intracranial location of the 100-millisecond latency auditory-evoked field component (M100) in both left and right hemispheres of 20 patients with paranoid schizophrenia and 20 controls without schizophrenia. Neuroanatomical data were obtained by means of magnetic resonance imaging, from which we segmented and computed volumes of both total brain and left and right superior temporal gyri.
Results
Locations of M100 source were compatible with neuronal generators located in the transverse gyri of Heschl on the superior temporal gyri in both study groups; M100 sources were asymmetric in all the control subjects. The male patient subgroup exhibited significantly less asymmetry than the control group, while the female patient subgroup actually showed significantly more asymmetry. The male patient subgroup generally had smaller superior temporal gyri than the control group. No evidence of total brain volume differences was observed.
Conclusions
Our findings support previous magnetoencephalography-based studies suggesting anomalous cerebral lateralization in schizophrenia. Further, in extending our studies to female patients, our data suggest that the nature of this anomaly is sex specific, a finding that, to our knowledge, has not previously been reported.
Author Affiliations
From the Departments of Psychiatry (Drs Reite and Rojas and Ms Sheeder and Mssrs Teale, Adams, and Richardson), Radiology (Dr Simon), and Preventive Medicine and Biometrics (Dr Jones), University of Colorado Health Sciences Center; and Psychiatry Service, Denver Veterans Affairs Medical Center (Dr Reite), Denver.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Sex Differences in Language Dysfunction in Schizophrenia
Walder et al.
Am. J. Psychiatry 2006;163:470-477.
ABSTRACT
| FULL TEXT
Anomalous Somatosensory Cortical Localization in Schizophrenia
Reite et al.
Am. J. Psychiatry 2003;160:2148-2153.
ABSTRACT
| FULL TEXT
Impact of Normal Sexual Dimorphisms on Sex Differences in Structural Brain Abnormalities in Schizophrenia Assessed by Magnetic Resonance Imaging
Goldstein et al.
Arch Gen Psychiatry 2002;59:154-164.
ABSTRACT
| FULL TEXT
Handedness, language lateralisation and anatomical asymmetry in schizophrenia: Meta-analysis
SOMMER et al.
Br. J. Psychiatry 2001;178:344-351.
ABSTRACT
| FULL TEXT
Sex Differences in Inferior Parietal Lobule Volume in Schizophrenia
Frederikse et al.
Am. J. Psychiatry 2000;157:422-427.
ABSTRACT
| FULL TEXT
Bipolar Disorder: Anomalous Brain Asymmetry Associated With Psychosis
Reite et al.
Am. J. Psychiatry 1999;156:1159-1163.
ABSTRACT
| FULL TEXT
Cortical Abnormalities in Schizophrenia Identified by Structural Magnetic Resonance Imaging
Goldstein et al.
Arch Gen Psychiatry 1999;56:537-547.
ABSTRACT
| FULL TEXT
Psychopathology in Women and Men: Focus on Female Hormones
Seeman
Am. J. Psychiatry 1997;154:1641-1647.
ABSTRACT
| FULL TEXT
Sex-Specific Expression of Heschl's Gyrus Functional and Structural Abnormalities in Paranoid Schizophrenia
Rojas et al.
Am. J. Psychiatry 1997;154:1655-1662.
ABSTRACT
| FULL TEXT
|
