 |
|
Hormonal and Subjective Responses to Intravenous meta-Chlorophenylpiperazine in Bulimia Nervosa
Robert D. Levitan, MD;
Allan S. Kaplan, MD;
Russell T. Joffe, MD;
Anthony J. Levitt, MD;
Gregory M. Brown, MD
Arch Gen Psychiatry. 1997;54(6):521-527.
Abstract
Background
Several lines of evidence point to serotonergic abnormalities in patients with bulimia nervosa (BN). Our goal was to further examine central serotonergic function in bulimic patients using neuroendocrine and subjective responses to the postsynaptic serotonin receptor agonist meta-chlorophenylpiperazine (mCPP).
Method
Using a double-blind, randomized, placebo-controlled design, we assessed neuroendocrine and subjective responses to intravenous mCPP (0.1 mg/kg) and placebo in 16 patients with BN, free of medication, and 14 normal control subjects. Plasma prolactin and cortisol levels were used as neuroendocrine measures, whereas subjective responses were measured using a visual analog scale of 10 different mood states.
Results
Compared with controls, the BN group exhibited blunted prolactin and net cortisol responses following mCPP challenge. Subjective responses, while preliminary, also differed between groups on items related to anxiety, calmness, and altered self-awareness.
Conclusion
Evidence of dysfunction at or downstream of central serotonergic receptors in BN confirms and extends findings of prior research.
Author Affiliations
From the Eating Disorders Center, The Toronto Hospital (Drs Levitan and Kaplan), and the Clarke Institute of Psychiatry (Drs Joffe, Levitt, and Brown), Department of Psychiatry University of Toronto, Toronto, Ontario. Dr Levitan is now at the Mood Disorders Clinic, Clarke Institute of Psychiatry, Toronto. Dr Joffe is now with the Department of Psychiatry, McMaster University, Hamilton, Ontario. Dr Levitt is now at the Mood Disorders Clinic, Sunnybrook Hospital, Department of Psychiatry, University of Toronto.
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Association of Serotonin and Cortisol Indices With Childhood Abuse in Bulimia Nervosa
Steiger et al.
Arch Gen Psychiatry 2001;58:837-843.
ABSTRACT
| FULL TEXT
Symptomatic Relapse in Bulimia Nervosa Following Acute Tryptophan Depletion
Smith et al.
Arch Gen Psychiatry 1999;56:171-176.
ABSTRACT
| FULL TEXT
Alterations in Serotonin Activity and Psychiatric Symptoms After Recovery From Bulimia Nervosa
Kaye et al.
Arch Gen Psychiatry 1998;55:927-935.
ABSTRACT
| FULL TEXT
Hormonal and Subjective Responses to Intravenous m-Chlorophenylpiperazine in Women With Seasonal Affective Disorder
Levitan et al.
Arch Gen Psychiatry 1998;55:244-249.
ABSTRACT
| FULL TEXT
Biopsychosocial Etiology of Bulimia Nervosa
JWatch Psychiatry 1997;1997:13-13.
FULL TEXT
Models to Conceptualize Risk Factors for Bulimia Nervosa
Halmi
Arch Gen Psychiatry 1997;54:507-508.
ABSTRACT
|
