Frontostriatal Measurement in Treatment-Naive Children With Obsessive-Compulsive Disorder

doi:10.1001/archpsyc.1997.01830210068007

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Vol. 54 No. 9, September 1997

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Frontostriatal Measurement in Treatment-Naive Children With Obsessive-Compulsive Disorder

David R. Rosenberg, MD; Matcheri S. Keshavan, MD; Kirsten M. O'Hearn; Elizabeth L. Dick; Werner W. Bagwell; Andrew B. Seymour; Debra M. Montrose, MSW; Joseph N. Pierri, MS, MD; Boris Birmaher, MD

Arch Gen Psychiatry. 1997;54(9):824-830.

Abstract

Background
Abnormalities in frontostriatal circuits have been implicatedin obsessive-compulsive disorder (OCD). Although OCD commonlyemerges during childhood or adolescence, few studies have examinedfrontostriatal anatomy in psychotropic-naive children with OCDnear the onset of illness to determine the possible role ofatypical developmental processes in this disorder.

Methods
Magnetic resonance imaging scans from 19 children with OCD whohad not been exposed to psychotropic drugs, aged 7 to 18 years,and 19 casematched healthy control subjects were analyzed todetermine the volumes of the following structures: prefrontalcortex, striatum (caudate and putamen), lateral and third ventricles,and intracranial volume.

Results
Patients with OCD had significantly smaller striatal volumesand significantly larger third ventricle volumes than controls,but did not differ in prefrontal cortical, lateral ventricular,or intracranial volumes. Striatal volumes were inversely correlatedwith OCD symptom severity but not illness duration.

Conclusions
Our findings provide new evidence of abnormalities of the striatumin pediatric OCD. These results are preliminary, given the smallsample

Author Affiliations

From the Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pa. Dr Rosenberg is now affiliated with the Department of Psychiatry, Behavioral Neurosciences, and Pediatrics, Wayne State University School of Medicine, Detroit, Mich.

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