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Association Between the Tryptophan Hydroxylase Gene and Manic-depressive Illness
Frank Bellivier, MD;
Marion Leboyer, MD, PhD;
Philippe Courtet, MD;
Catherine Buresi, MD, PhD;
Béatrice Beaufils, MD;
Danielle Samolyk;
Jean-François Allilaire, MD;
Josue Feingold, MD, PhD;
Jacques Mallet, PhD;
Alain Malafosse, MD, PhD
Arch Gen Psychiatry. 1998;55:33-37.
Background Genes encoding proteins involved in serotonergic metabolism are major candidates in association studies of mood disorders and suicidal behavior. This association study explores whether the tryptophan hydroxylase (TPH) gene, which codes for the rate-limiting enzyme of serotonin biosynthesis, is a susceptibility factor for manic-depressive illness, with or without a history of suicide attempts.
Methods The TPH intron 7 A218C polymorphism was determined using a polymerase chain reaction–based method in DNA samples from 152 patients with bipolar disorder and 94 healthy control subjects.
Results There was a significant association between TPH genotypes and manic-depressive illness. Among patients with bipolar disorder, no association was found between TPH alleles and suicidal behavior.
Conclusions This result suggests the involvement of the TPH gene in susceptibility to manic-depressive illness. This preliminary result requires confirmation in further groups of patients and controls.
From the Laboratoire de Recherche sur les Personnalités et les Conduites Adaptatives (Drs Bellivier and Leboyer), Service de Psychiatrie Adulte (Drs Leboyer and Allilaire), and Laboratoire de Génétique de la Neurotransmission et des Processus Neurodégénératifs (Dr Mallet and Ms Samolyk), Hôpital Pitié-Salpétrière, and Laboratoire d'Epidémiologie Génétique (Drs Bellivier and Feingold), Paris, France; Service de Psychiatrie Adulte, Hôpital Corentin Celton, Issy-les-Moulineaux, France (Dr Beaufils); and Division de Neuropsychiatrie, Hopitaux Universitaires de Genève, Geneva, Switzerland (Drs Courtet, Buresi, and Malafosse).
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