This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (59)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Schizophrenia  • Alert me on articles by topic  Social Bookmarking   What's this?

Evidence From Automated Analyses of Sleep Data

Matcheri S. Keshavan, MD; Charles F. Reynolds III, MD; Jean M. Miewald, BA; Debra M. Montrose, MSW; John A. Sweeney, PhD; Raymond C. Vasko, Jr, PhD; David J. Kupfer, MD

Arch Gen Psychiatry. 1998;55:443-448.

Background  Several, though not all, polysomnographic studies that use conventional visual scoring techniques show delta sleep deficits in schizophrenia. Delta sleep (in particular, 1- to 2-Hz frequency range), mediated by thalamocortical circuits, is postulated to be abnormal in schizophrenia. We investigated whether deficits in delta sleep occur in schizophrenia and whether these are primarily related to the illness or are epiphenomena of previous medication use or illness chronicity.

Methods  We compared 30 unmedicated schizophrenic patients and 30 age- and sex-matched controls for sleep data evaluated by visual scoring as well as automated period amplitude analyses and power spectral analyses.

Results  Schizophrenic patients had reduced visually scored delta sleep. Period amplitude analyses showed significant reductions in delta wave counts but not rapid eye movement counts; power spectral analyses showed reductions in delta as well as theta power. Delta spectral power was also reduced in the subset of 19 neuroleptic-naive, first-episode schizophrenic patients compared with matched controls. Delta deficits were more pronounced in the greater than 1- to 2-Hz frequency range.

Conclusions  Delta sleep deficits that occur in schizophrenia may be related to the primary pathophysiological characteristics of the illness and may not be secondary to previous neuroleptic use. Automated sleep quantification by means of period amplitude and power spectral analyses can complement the use of conventional visual scoring for understanding electrophysiological abnormalities in psychiatric disorders.

From the Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pa.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Reduced Frontal Asymmetry of Delta Waves During All-Night Sleep in Schizophrenia
Sekimoto et al.
Schizophr Bull 2007;33:1307-1311.
ABSTRACT | FULL TEXT  

Reduced Sleep Spindle Activity in Schizophrenia Patients
Ferrarelli et al.
Am. J. Psychiatry 2007;164:483-492.
ABSTRACT | FULL TEXT  

Delta Power in Sleep in Relation to Neuropsychological Performance in Healthy Subjects and Schizophrenia Patients
Goder et al.
J. Neuropsychiatry Clin. Neurosi. 2006;18:529-535.
ABSTRACT | FULL TEXT  

Alterations in Regional Cerebral Glucose Metabolism Across Waking and Non-Rapid Eye Movement Sleep in Depression
Nofzinger et al.
Arch Gen Psychiatry 2005;62:387-396.
ABSTRACT | FULL TEXT  

Increased Activation of Anterior Paralimbic and Executive Cortex From Waking to Rapid Eye Movement Sleep in Depression
Nofzinger et al.
Arch Gen Psychiatry 2004;61:695-702.
ABSTRACT | FULL TEXT  

Increases in Regional Subarachnoid CSF Without Apparent Cortical Gray Matter Deficits in Schizophrenia: Modulating Effects of Sex and Age
Narr et al.
Am. J. Psychiatry 2003;160:2169-2180.
ABSTRACT | FULL TEXT  

Human regional cerebral glucose metabolism during non-rapid eye movement sleep in relation to waking
Nofzinger et al.
Brain 2002;125:1105-1115.
ABSTRACT | FULL TEXT  

Sleep, Memory Maintenance, and Mental Disorders
Kavanau
J. Neuropsychiatry Clin. Neurosi. 2000;12:199-208.
ABSTRACT | FULL TEXT