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Sofia Avissar, PhD; Gabriel Schreiber, MD, PhD; Yakov Nechamkin, MD; Isaac Neuhaus, BA; Gregory K. Lam, BS; Paul Schwartz, MD; Erick Turner, MD; Jeffery Matthews, MD; Susana Naim, MD; Norman E. Rosenthal, MD

Arch Gen Psychiatry. 1999;56:178-183.

Background  Information-transducing heterotrimeric G proteins have been implicated previously in the mechanism of action of mood stabilizers and in the pathophysiology of mood disorders. Mononuclear leukocytes of patients with unipolar and bipolar depression have been characterized by reduced measures of the stimulatory and inhibitory G proteins. In this study, patients with seasonal affective disorder (SAD) were measured for mononuclear leukocyte G protein levels while depressed during the winter, following light therapy, and in remission during the summer.

Methods  Twenty-six patients with SAD and 28 healthy subjects were assessed in the study. The immunoreactivities of G_s, G_i, and G subunit proteins were determined by Western blot analysis of mononuclear leukocyte membranes with selective polyclonal antibodies for the various G subunit proteins, followed by densitometric quantitation using an image analysis system.

Results  Untreated patients with SAD and winter, atypical-type depression showed significantly reduced mononuclear leukocyte immunoreactive levels of G_s and G_i proteins, similar to previous observations in patients with nonseasonal major depression. The reduced G protein levels were normalized with 2 weeks of light therapy. The same patients while in remission during the summer had G protein levels that were similar to those of healthy subjects.

Conclusions  G protein–immunoreactive measures in patients with SAD are suggested as a state marker for winter depression, which is normalized by light treatment and during the summer. We speculate that light may exert its effects via normalization of transducin (G_t protein) levels, which are thought to be reduced in winter depression.

From the Departments of Clinical Pharmacology (Dr Avissar) and Psychiatry (Drs Schreiber and Nechamkin), Faculty for Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel (Drs Avissar, Schreiber, and Nechamkin); and Clinical Psychobiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Md (Messrs Neuhaus and Lam and Drs Schwartz, Turner, Matthews, Naim, and Rosenthal).

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