
Genetic Case-Control Association Studies in Neuropsychiatry
Patrick F. Sullivan, MD, FRANZCP;
Lindon J. Eaves, PhD, DSc;
Kenneth S. Kendler, MD;
Michael C. Neale, PhD
Arch Gen Psychiatry. 2001;58:1015-1024.
Case-control association studies use genetic markers as putative etiologic
risk factors. The approach is controversial and has tended to produce associations
in neuropsychiatry that do not stand the test of time. We studied the processes
that can bias the outcomes away from a true representation of the relationship
between a genetic marker and a neuropsychiatric disorder. If conducted with
care and mindfulness of the potential pitfalls, case-control association studies
can be an important tool for psychiatric genetic research.
From the Virginia Institute for Psychiatric and Behavioral Genetics,
Virginia Commonwealth University, Richmond.
Corresponding author and reprints: Patrick F. Sullivan, MD, FRANZCP,
Virginia Institute for Psychiatric and Behavioral Genetics, PO Box 980126,
Richmond, VA 23298-0126 (e-mail: sullivan{at}psycho.psi.vcu.edu).
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