 |
|
Blunted Prefrontal Cortical 18Fluorodeoxyglucose Positron Emission Tomography Response to Meta-Chlorophenylpiperazine in Impulsive Aggression
Antonia S. New, MD;
Erin A. Hazlett, PhD;
Monte S. Buchsbaum, MD;
Marianne Goodman, MD;
Diedre Reynolds, MD;
Vivian Mitropoulou, MA;
Larry Sprung, BA;
Robert B. Shaw, Jr, BS;
Harold Koenigsberg, MD;
Jimcy Platholi, MA;
Jeremy Silverman, PhD;
Larry J. Siever, MD
Arch Gen Psychiatry. 2002;59:621-629.
Background Impulsive aggression is a prevalent problem and yet little is known
about its neurobiology. Preclinical and human studies suggest that the orbital
frontal cortex and anterior cingulate cortex play an inhibitory role in the
regulation of aggression.
Methods Using positron emission tomography, regional metabolic activity in response
to a serotonergic stimulus, meta-chlorophenylpiperazine (m-CPP), was examined
in 13 subjects with impulsive aggression and 13 normal controls. The anterior
cingulate and medial orbitofrontal regions were hypothesized to respond differentially
to m-CPP in patients and controls. In the frontal cortex, regional metabolic
glucose response to m-CPP was entered into a group (impulsive aggressive,
control) x slice (dorsal, middle, orbital) x position (medial,
lateral) x location (anterior, posterior) x hemisphere (right,
left) mixed-factorial analysis of variance design. A separate group (impulsive
aggressive, controls) x anteroposterior location (Brodmann areas 25,
24, 31, 29) x hemisphere (right, left) analysis of variance was used
to examine regional glucose metabolism in the cingulate gyrus.
Results Unlike normal subjects, patients with impulsive aggression did not show
activation specifically in the left anteromedial orbital cortex in response
to m-CPP. The anterior cingulate, normally activated by m-CPP, was deactivated
in patients; in contrast, the posterior cingulate gyrus was activated in patients
and deactivated in controls.
Conclusions The decreased activation of inhibitory regions in patients with impulsive
aggression in response to a serotonergic stimulus may contribute to their
difficulty in modulating aggressive impulses.
From the Psychiatry Service, Bronx Veterans Affairs Medical Center,
Bronx, NY (Drs New, Goodman, Reynolds, Koenigsberg, Silverman, and Siever,
Ms Mitropoulou, and Mr Sprung); the Department of Psychiatry (Drs New, Hazlett,
Buchsbaum, Goodman, Reynolds, Koenigsberg, Silverman, and Siever, Ms Mitropoulou,
and Messrs Sprung and Shaw), and the Neuroscience PET Laboratory (Drs Hazlett
and Buchsbaum, Mr Shaw, and Ms Platholi), Mount Sinai School of Medicine,
New York, NY.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Neural foundations to moral reasoning and antisocial behavior
Raine and Yang
Soc Cogn Affect Neurosci 2006;1:203-213.
ABSTRACT
| FULL TEXT
Corticolimbic Blood Flow During Nontraumatic Emotional Processing in Posttraumatic Stress Disorder
Phan et al.
Arch Gen Psychiatry 2006;63:184-192.
ABSTRACT
| FULL TEXT
Brain Serotonin Transporter Distribution in Subjects With Impulsive Aggressivity: A Positron Emission Study With [11C]McN 5652
Frankle et al.
Am. J. Psychiatry 2005;162:915-923.
ABSTRACT
| FULL TEXT
Impaired Decision Making in Suicide Attempters
Jollant et al.
Am. J. Psychiatry 2005;162:304-310.
ABSTRACT
| FULL TEXT
Ventromedial Prefrontal Cortex and Amygdala Dysfunction During an Anger Induction Positron Emission Tomography Study in Patients With Major Depressive Disorder With Anger Attacks
Dougherty et al.
Arch Gen Psychiatry 2004;61:795-804.
ABSTRACT
| FULL TEXT
The Application of the Principles of Clinical Drug Development to Pharmacological Challenge Tests of the Serotonergic System
Gijsman et al.
J Psychopharmacol 2004;18:7-13.
ABSTRACT
An fMRI Stroop Task Study of Ventromedial Prefrontal Cortical Function in Pathological Gamblers
Potenza et al.
Am. J. Psychiatry 2003;160:1990-1994.
ABSTRACT
| FULL TEXT
Gambling Urges in Pathological Gambling: A Functional Magnetic Resonance Imaging Study
Potenza et al.
Arch Gen Psychiatry 2003;60:828-836.
ABSTRACT
| FULL TEXT
Reduced Serotonergic Influence May Contribute to Impulsive Aggression
JWatch Psychiatry 2002;2002:6-6.
FULL TEXT
|
