 |
|
Fusiform Gyrus Volume Reduction in First-Episode Schizophrenia
A Magnetic Resonance Imaging Study
Chang Uk Lee, MD, PhD;
Martha E. Shenton, PhD;
Dean F. Salisbury, PhD;
Kiyoto Kasai, MD;
Toshiaki Onitsuka, MD, PhD;
Chandlee C. Dickey, MD;
Deborah Yurgelun-Todd, PhD;
Ron Kikinis, MD;
Ferenc A. Jolesz, MD;
Robert W. McCarley, MD
Arch Gen Psychiatry. 2002;59:775-781.
Background The fusiform gyrus (occipitotemporal gyrus) is thought to be critical
for face recognition and may possibly be associated with impaired facial recognition
and interpretation of facial expression in schizophrenia. of postmortem studies
have suggested that fusiform gyrus volume is reduced in schizophrenia, but
there have been no in vivo structural studies of the fusiform gyrus in schizophrenia
using magnetic resonance imaging.
Methods High–spatial resolution magnetic resonance images were used to
measure the gray matter volume of the fusiform gyrus in 22 patients with first-episode
schizophrenia (first hospitalization), 20 with first-episode affective psychosis
(mainly manic), and 24 control subjects.
Results Patients with first-episode schizophrenia had overall smaller relative
volumes (absolute volume/intracranial contents) of fusiform gyrus gray matter
compared with controls (9%) and patients with affective psychosis (7%). For
the left fusiform gyrus, patients with schizophrenia showed an 11% reduction
compared with controls and patients with affective psychosis. Right fusiform
gyrus volume differed in patients with schizophrenia only compared with controls
(8%).
Conclusion Schizophrenia is associated with a bilateral reduction in fusiform gyrus
gray matter volume that is evident at the time of first hospitalization and
is different from the presentation of affective psychosis.
From the Clinical Neuroscience Division, Laboratory of Neuroscience,
Department of Psychiatry, VA Boston Healthcare System, Brockton Division,
and Harvard Medical School, Brockton, Mass (Drs Lee, Shenton, Salisbury, Kasai,
Onitsuka, Dickey, and McCarley); the Cognitive Neuroscience Laboratory (Dr
Salisbury) and the Brain Imaging Center (Dr Yurgelun-Todd), McLean Hospital,
Belmont, Mass; and the Surgical Planning Laboratory, MRI Division, Brigham
and Women's Hospital, Department of Radiology, Harvard Medical School, Boston,
Mass (Drs Shenton, Kikinis, and Jolesz). Dr Lee is now with the Department
of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Dysfunction in Configural Face Processing in Patients With Schizophrenia
Shin et al.
Schizophr Bull 2008;34:538-543.
ABSTRACT
| FULL TEXT
An fMRI Study of Saccadic and Smooth-Pursuit Eye Movement Control in Patients with Age-Related Macular Degeneration
Little et al.
IOVS 2008;49:1728-1735.
ABSTRACT
| FULL TEXT
Inefficient Face Detection in Schizophrenia
Chen et al.
Schizophr Bull 2008;34:367-374.
ABSTRACT
| FULL TEXT
Structural Imaging Reveals Anatomical Alterations in Inferotemporal Cortex in Congenital Prosopagnosia
Behrmann et al.
Cereb Cortex 2007;17:2354-2363.
ABSTRACT
| FULL TEXT
Brain volume in first-episode schizophrenia: Systematic review and meta-analysis of magnetic resonance imaging studies
STEEN et al.
Br. J. Psychiatry 2006;188:510-518.
ABSTRACT
| FULL TEXT
Association Between Reduced Extraversion and Right Posterior Fusiform Gyrus Gray Matter Reduction in Chronic Schizophrenia
Onitsuka et al.
Am. J. Psychiatry 2005;162:599-601.
ABSTRACT
| FULL TEXT
Early-Stage Face Processing Dysfunction in Patients With Schizophrenia
Herrmann et al.
Am. J. Psychiatry 2004;161:915-917.
ABSTRACT
| FULL TEXT
Differences and Similarities in Insular and Temporal Pole MRI Gray Matter Volume Abnormalities in First-Episode Schizophrenia and Affective Psychosis
Kasai et al.
Arch Gen Psychiatry 2003;60:1069-1077.
ABSTRACT
| FULL TEXT
Progressive Decrease of Left Heschl Gyrus and Planum Temporale Gray Matter Volume in First-Episode Schizophrenia: A Longitudinal Magnetic Resonance Imaging Study
Kasai et al.
Arch Gen Psychiatry 2003;60:766-775.
ABSTRACT
| FULL TEXT
Fusiform Gyrus Volume Reduction and Facial Recognition in Chronic Schizophrenia
Onitsuka et al.
Arch Gen Psychiatry 2003;60:349-355.
ABSTRACT
| FULL TEXT
|
