 |
|
Familial Pathways to Early-Onset Suicide Attempt
Risk for Suicidal Behavior in Offspring of Mood-Disordered Suicide Attempters
David A. Brent, MD;
Maria Oquendo, MD;
Boris Birmaher, MD;
Laurence Greenhill, MD;
David Kolko, PhD;
Barbara Stanley, PhD;
Jamie Zelazny, BSN;
Beth Brodsky, PhD;
Jeffrey Bridge, PhD;
Steve Ellis, PhD;
J. Octavio Salazar, MD;
J. John Mann, MD
Arch Gen Psychiatry. 2002;59:801-807.
Background Although adoption, twin, and family studies have shown that suicidal
behavior is familial, the risk factors for familial transmission from parent
to child remain unclear.
Methods A high-risk family study was conducted comparing the offspring of 2
mood-disordered groups: suicide attempters and nonattempters. Recruited from
2 sites, probands were 81 attempters and 55 nonattempters, with 183 and 116
offspring, respectively. Offspring were assessed by investigators masked to
proband status. Probands and offspring were assessed with respect to psychopathologic
findings, suicide attempt history, impulsive aggression, and exposure to familial
environmental stressors.
Results Offspring of attempters had a 6-fold increased risk of suicide attempts
relative to offspring of nonattempters. Familial transmission of suicide attempt
was more likely if (1) probands had a history of sexual abuse and (2) offspring
were female and had a mood disorder, substance abuse disorder, increased impulsive
aggression, and a history of sexual abuse.
Conclusions The offspring of mood-disordered suicide attempters are at markedly
increased risk for suicide attempts themselves. Familial transmission of suicidal
behavior in families with mood disorders almost always requires transmission
of a mood disorder and is also related to the offspring's impulsive aggression
and the familial transmission of sexual abuse. Early treatment of mood disorders
and targeting impulsive aggression and sexual trauma may be helpful in the
prevention and treatment of suicidal behavior in families with mood disorders.
From the Western Psychiatric Institute and Clinic (Drs Brent, Birmaher,
Kolko, and Bridge and Ms Zelazny) and St Francis Medical Center (Dr Salazar),
Pittsburgh, Pa; and New York State Psychiatric Institute, New York City (Drs
Oquendo, Greenhill, Stanley, Brodsky, Ellis, and Mann).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
A Developmental Perspective on the Controversy Surrounding the Use of SSRIs to Treat Pediatric Depression
Leckman and King
Am. J. Psychiatry 2007;164:1304-1306.
FULL TEXT
Familial Pathways to Early-Onset Suicidal Behavior: Familial and Individual Antecedents of Suicidal Behavior
Melhem et al.
Am. J. Psychiatry 2007;164:1364-1370.
ABSTRACT
| FULL TEXT
What Have We Learned About the Neurobiology of Major Depression?
Oquendo and Parsey
Am. J. Psychiatry 2007;164:540-542.
FULL TEXT
Death by Unnatural Causes During Childhood and Early Adulthood in Offspring of Psychiatric Inpatients
Webb et al.
Arch Gen Psychiatry 2007;64:345-352.
ABSTRACT
| FULL TEXT
The Role of Psychosocial Stress in the Onset and Progression of Bipolar Disorder and its Comorbidities: The Need for Earlier and Alternative Modes of Therapeutic Intervention
Post and Leverich
Focus 2007;5:73-97.
ABSTRACT
| FULL TEXT
Sex Differences in Clinical Predictors of Suicidal Acts After Major Depression: A Prospective Study
Oquendo et al.
Am. J. Psychiatry 2007;164:134-141.
ABSTRACT
| FULL TEXT
Mortality Risk Among Offspring of Psychiatric Inpatients: A Population-Based Follow-Up to Early Adulthood
Webb et al.
Am. J. Psychiatry 2006;163:2170-2177.
ABSTRACT
| FULL TEXT
Implication of SSAT by Gene Expression and Genetic Variation in Suicide and Major Depression
Sequeira et al.
Arch Gen Psychiatry 2006;63:35-48.
ABSTRACT
| FULL TEXT
Maternal Suicidality and Risk of Suicidality in Offspring: Findings From a Community Study
Lieb et al.
Am. J. Psychiatry 2005;162:1665-1671.
ABSTRACT
| FULL TEXT
Family History of Suicidal Behavior and Mood Disorders in Probands With Mood Disorders
Mann et al.
Am. J. Psychiatry 2005;162:1672-1679.
ABSTRACT
| FULL TEXT
Mortality in Offspring of Parents With Psychotic Disorders: A Critical Review and Meta-Analysis
Webb et al.
Am. J. Psychiatry 2005;162:1045-1056.
ABSTRACT
| FULL TEXT
Familial Aggregation of Suicidal Behavior: A Family Study of Male Suicide Completers From the General Population
Kim et al.
Am. J. Psychiatry 2005;162:1017-1019.
ABSTRACT
| FULL TEXT
Correlates and Predictors of Self-Reported Suicide Attempts Among Incarcerated Youths
Putnins
Int J Offender Ther Comp Criminol 2005;49:143-157.
ABSTRACT
Posttraumatic Stress Disorder Comorbid With Major Depression: Factors Mediating the Association With Suicidal Behavior
Oquendo et al.
Am. J. Psychiatry 2005;162:560-566.
ABSTRACT
| FULL TEXT
Prospective Study of Clinical Predictors of Suicidal Acts After a Major Depressive Episode in Patients With Major Depressive Disorder or Bipolar Disorder
Oquendo et al.
Am. J. Psychiatry 2004;161:1433-1441.
ABSTRACT
| FULL TEXT
Peripubertal Suicide Attempts in Offspring of Suicide Attempters With Siblings Concordant for Suicidal Behavior
Brent et al.
Am. J. Psychiatry 2003;160:1486-1493.
ABSTRACT
| FULL TEXT
Familial Risk for Suicide
JWatch Psychiatry 2002;2002:9-9.
FULL TEXT
Researchers Find Answers To Familial-Suicide Puzzle
Arehart-Treichel
Psychiatr. News 2002;37:33-33.
FULL TEXT
|
