 |
|
Mismatch Negativity Deficits Are Associated With Poor Functioning in Schizophrenia Patients
Gregory A. Light, PhD;
David L. Braff, MD
Arch Gen Psychiatry. 2005;62:127-136.
Background Schizophrenia patients exhibit widespread deficits in many domains, ranging from abnormalities in preattentional sensory processing to gross impairments in everyday functioning. Mismatch negativity (MMN) is an event-related potential measure that occurs in the absence of directed attention. While many studies have reported MMN deficits in schizophrenia patients, little is known about the functional significance of MMN deficits in schizophrenia patients.
Objective To determine if a schizophrenia-linked deficit in MMN, an "automatic" preattentional measure, is associated with impairments in everyday functional status, level of independence in living situation, and the ability to perform tasks routinely encountered in everyday situations.
Setting and Participants Twenty-five patients with a DSM-IV diagnosis of schizophrenia recruited from inpatient and outpatient community facilities affiliated with the University of California, San Diego, and 25 healthy, nonpsychiatric, comparison subjects.
Main Outcome Measures Mismatch negativity, clinical symptoms, performance on a multidimensional laboratory-based functional skills assessment battery, clinician ratings on the Global Assessment of Functioning Scale, and level of independence in community living situation.
Results Schizophrenia patients had significantly reduced MMN (P<.001). Greater levels of MMN impairment were associated with lower Global Assessment of Functioning Scale ratings. Consistent with clinical ratings, patients with greater MMN impairments were more likely to live in highly structured vs independent settings. A regional analysis of MMN revealed that the largest correlations of MMN to everyday functioning were present at frontocentral recording sites (eg, rs = –0.65). In contrast, MMN deficits were not associated with symptom severity or performance on laboratory-based tasks measuring skills that are often considered necessary for independent living.
Conclusions This pattern of results suggests that MMN deficits represent a core neurophysiological dysfunction that is linked to global impairments in everyday functioning in schizophrenia patients. These deficits in automatic preattentive information processing account for up to 42% of the variance in global functional status in schizophrenia patients. Thus, basic preattentional cognitive deficits may be excellent measures for predicting functional outcome. Longitudinal studies are needed to better understand the relationships between deficits in automatic sensory information processing, associated neural substrate dysfunctions, and deficits in everyday functioning across the course of the illness.
Author Affiliations: Department of Psychiatry, University of California, San Diego, La Jolla.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Deviance-elicited Changes in Event-related Potentials are Attenuated by Ketamine in Mice
Ehrlichman et al.
J. Cogn. Neurosci. 2008;20:1403-1414.
ABSTRACT
| FULL TEXT
Neurophysiological Endophenotypes Across Bipolar and Schizophrenia Psychosis
Thaker
Schizophr Bull 2008;34:760-773.
ABSTRACT
| FULL TEXT
Preattentive Sensory Processing as Indexed by the MMN and P3a Brain Responses is Associated with Cognitive and Psychosocial Functioning in Healthy Adults.
Light et al.
J. Cogn. Neurosci. 2007;19:1624-1632.
ABSTRACT
| FULL TEXT
Application of Electroencephalography to the Study of Cognitive and Brain Functions in Schizophrenia
van der Stelt and Belger
Schizophr Bull 2007;33:955-970.
ABSTRACT
| FULL TEXT
Progressive and Interrelated Functional and Structural Evidence of Post-Onset Brain Reduction in Schizophrenia
Salisbury et al.
Arch Gen Psychiatry 2007;64:521-529.
ABSTRACT
| FULL TEXT
Statistical Genetics Concepts and Approaches in Schizophrenia and Related Neuropsychiatric Research
Schork et al.
Schizophr Bull 2007;33:95-104.
ABSTRACT
| FULL TEXT
Neurophysiological Endophenotypes of Schizophrenia: The Viability of Selected Candidate Measures
Turetsky et al.
Schizophr Bull 2007;33:69-94.
ABSTRACT
| FULL TEXT
Startle Gating Deficits in a Large Cohort of Patients With Schizophrenia: Relationship to Medications, Symptoms, Neurocognition, and Level of Function
Swerdlow et al.
Arch Gen Psychiatry 2006;63:1325-1335.
ABSTRACT
| FULL TEXT
Event-Related Brain Potential Correlates of Human Auditory Sensory Memory-Trace Formation
Haenschel et al.
J. Neurosci. 2005;25:10494-10501.
ABSTRACT
| FULL TEXT
Developing Drugs for Cognitive Impairment in Schizophrenia
Breier
Schizophr Bull 2005;31:816-822.
ABSTRACT
| FULL TEXT
Functional Neuroimaging and Electrophysiology Biomarkers for Clinical Trials for Cognition in Schizophrenia
Cho et al.
Schizophr Bull 2005;31:865-869.
ABSTRACT
| FULL TEXT
Stability of Mismatch Negativity Deficits and Their Relationship to Functional Impairments in Chronic Schizophrenia
Light and Braff
Am. J. Psychiatry 2005;162:1741-1743.
ABSTRACT
| FULL TEXT
|
