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  Vol. 62 No. 4, April 2005 TABLE OF CONTENTS
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Impact of 3-Tier Formularies on Drug Treatment of Attention-Deficit/Hyperactivity Disorder in Children

Haiden A. Huskamp, PhD; Patricia A. Deverka, MD, MS; Arnold M. Epstein, MD, MA; Robert S. Epstein, MD, MS; Kimberly A. McGuigan, PhD; Anna C. Muriel, MD; Richard G. Frank, PhD

Arch Gen Psychiatry. 2005;62:435-441.

Background  Expenditures for medications used to treat attention-deficit/hyperactivity disorder (ADHD) in children have increased rapidly. Many employers and health plans have adopted 3-tier formularies in an attempt to control costs for these and other drugs.

Objective  To assess the effect of copayment increases associated with 3-tier formulary adoption on use and spending patterns for ADHD medications for children.

Design and Setting  Observational study using quasi-experimental design to compare effects on ADHD medication use and spending for children enrolled as dependents in an employer-sponsored plan that made major changes to its pharmacy benefit design and a comparison group of children covered by the same insurer. The plan simultaneously moved from a 1-tier (same copayment required for all drugs) to a 3-tier formulary and implemented an across-the-board copayment increase. The plan later moved 3 drugs from tier 3 to tier 2.

Participants  An intervention group of 20 326 and a comparison group of 15 776 children aged 18 years and younger.

Main Outcome Measures  Monthly probability of using an ADHD medication; plan, enrollee, and total ADHD medication spending; and medication continuation.

Results  A 3-tier formulary implementation resulted in a 17% decrease in the monthly probability of using medication (P<.001), a 20% decrease in expected total medication expenditures, and a substantial shifting of costs from the plan to families (P<.001). Intervention group children using medications in the pre-period were more likely to change to a medication in a different tier after 3-tier adoption, relative to the comparison group (P = .08). The subsequent tier changes resulted in increased plan spending (P<.001) and decreased patient spending (P = .003) for users but no differences in continuation.

Conclusions  The copayment increases associated with 3-tier formulary implementation by 1 employer resulted in lower total ADHD medication spending, sizeable increases in out-of-pocket expenditures for families of children with ADHD, and a significant decrease in the probability of using these medications.


Author Affiliations: Departments of Health Care Policy (Drs Huskamp and Frank) and Psychiatry (Dr Muriel), Harvard Medical School, Boston, Mass; Medco Health Solutions Inc (Drs Deverka, Epstein, and McGuigan), Franklin Lakes, NJ; Department of Health Policy and Management, Harvard School of Public Health (Dr Epstein), Boston; Section on Health Services and Policy Research, Department of Medicine, Brigham and Women’s Hospital (Dr Epstein), Boston; Department of Psychiatry, Massachusetts General Hospital (Dr Muriel), Boston. Dr Deverka is currently a Fellow at Duke University, Institute for Genome Sciences and Policy, Durham, NC, and Dr McGuigan is now an employee of Pfizer, New York, NY.



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