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Amygdala Volume and Nonverbal Social Impairment in Adolescent and Adult Males With Autism
Brendon M. Nacewicz, BS;
Kim M. Dalton, PhD;
Tom Johnstone, PhD;
Micah T. Long, BS;
Emelia M. McAuliff, BS;
Terrence R. Oakes, PhD;
Andrew L. Alexander, PhD;
Richard J. Davidson, PhD
Arch Gen Psychiatry. 2006;63:1417-1428.
Background Autism is a syndrome of unknown cause, marked by abnormal development of social behavior. Attempts to link pathological features of the amygdala, which plays a key role in emotional processing, to autism have shown little consensus.
Objective To evaluate amygdala volume in individuals with autism spectrum disorders and its relationship to laboratory measures of social behavior to examine whether variations in amygdala structure relate to symptom severity.
Design We conducted 2 cross-sectional studies of amygdala volume, measured blind to diagnosis on high-resolution, anatomical magnetic resonance images. Participants were 54 males aged 8 to 25 years, including 23 with autism and 5 with Asperger syndrome or pervasive developmental disorder not otherwise specified, recruited and evaluated at an academic center for developmental disabilities and 26 age- and sex-matched community volunteers. The Autism Diagnostic Interview–Revised was used to confirm diagnoses and to validate relationships with laboratory measures of social function.
Main Outcome Measures Amygdala volume, judgment of facial expressions, and eye tracking.
Results In study 1, individuals with autism who had small amygdalae were slowest to distinguish emotional from neutral expressions (P=.02) and showed least fixation of eye regions (P=.04). These same individuals were most socially impaired in early childhood, as reported on the Autism Diagnostic Interview–Revised (P<.04). Study 2 showed smaller amygdalae in individuals with autism than in control subjects (P=.03) and group differences in the relation between amygdala volume and age. Study 2 also replicated findings of more gaze avoidance and childhood impairment in participants with autism with the smallest amygdalae. Across the combined sample, severity of social deficits interacted with age to predict different patterns of amygdala development in autism (P=.047).
Conclusions These findings best support a model of amygdala hyperactivity that could explain most volumetric findings in autism. Further psychophysiological and histopathological studies are indicated to confirm these findings.
Author Affiliations: Waisman Laboratory for Brain Imaging and Behavior (Messrs Nacewicz and Long, Drs Dalton, Johnstone, Oakes, Alexander, and Davidson, and Ms McAuliff), and Departments of Medical Physics (Dr Alexander), Psychiatry (Drs Alexander and Davidson), and Psychology (Dr Davidson), University of Wisconsin–Madison.
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