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Incidence of Schizophrenia in a Nationwide Cohort of Patients With Type 1 Diabetes Mellitus
Hannu Juvonen, MD;
Antti Reunanen, MD, PhD;
Jari Haukka, PhD;
Maria Muhonen, MD;
Jaana Suvisaari, MD, PhD;
Ritva Arajärvi, MD, PhD;
Timo Partonen, MD, PhD;
Jouko Lönnqvist, MD, PhD
Arch Gen Psychiatry. 2007;64(8):894-899.
Context Patients with schizophrenia have an increased risk of type 2 diabetes mellitus. However, very few studies have dealt with the association of type 1 diabetes and schizophrenia. Preliminary evidence points to a possible inverse association.
Objective To investigate the incidence of schizophrenia in a nationwide cohort of patients with type 1 diabetes born in 1950 through 1959 in Finland.
Design A cohort study of individuals born in 1950 through 1959 with a follow-up of 1969 through 1991.
Setting Finland.
Patients All individuals born in 1950 through 1959 with type 1 diabetes were identified through nationwide registers. The incidence of schizophrenia until 1992 among the total 1950-1959 cohort and in individuals with type 1 diabetes was calculated using information from 3 health care registers.
Main Outcome Measure Incidence of schizophrenia.
Results The incidence of schizophrenia was 0.21 per 10 000 person-years in the group with type 1 diabetes and 0.56 per 10 000 person-years in the group without type 1 diabetes (P < .001).
Conclusion The incidence of schizophrenia is decreased in patients with type 1 diabetes.
Author Affiliations: Departments of Mental Health and Alcohol Research (Drs Juvonen, Haukka, Muhonen, Suvisaari, Arajärvi, Partonen, and Lönnqvist) and Health and Functional Capacity (Dr Reunanen), National Public Health Institute, Helsinki, Finland.
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Diabetes Mellitus and Schizophrenia
Preben Bo Mortensen and William W. Eaton
Arch Gen Psychiatry. 2008;65(2):237-238.
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Diabetes Mellitus and Schizophrenia
Mortensen and Eaton
Arch Gen Psychiatry 2008;65:237-238.
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