 |
|
Association of Serotonin Transporter Gene Polymorphisms With Poststroke Depression
Ruth Kohen, MD;
Kevin C. Cain, PhD;
Pamela H. Mitchell, PhD;
Kyra Becker, MD;
Ann Buzaitis, MN, ARNP;
Steven P. Millard, PhD;
Grace P. Navaja, BS;
Linda Teri, PhD;
David Tirschwell, MD, MSc;
Richard Veith, MD
Arch Gen Psychiatry. 2008;65(11):1296-1302.
Context Polymorphisms of the serotonin transporter gene (SERT) have been associated with mental illness. In people with long-term medical conditions, variants of the 5-HTTLPR and STin2 VNTR polymorphisms of SERT have been shown to confer a heightened vulnerability to comorbid depression.
Objective To determine whether the 5-HTTLPR, STin2 VNTR, and rs25531 polymorphisms of SERT are associated with poststroke depression (PSD) in stroke survivors.
Design A case-control study in which stroke survivors were screened for depressive symptoms and assigned to either a depressed group or a nondepressed group.
Setting Outpatient clinic.
Participants Seventy-five stroke survivors with PSD and 75 nondepressed stroke survivors.
Interventions Blood or saliva samples were collected from each participant for DNA extraction and genotyping.
Main Outcome Measures The associations between the 5-HTTLPR, STin2 VNTR, and rs25531 polymorphisms and PSD.
Results Individuals with the 5-HTTLPR s/s genotype had 3-fold higher odds of PSD compared with l/l or l/xl genotype carriers (odds ratio, 3.1; 95% confidence interval, 1.2-8.3). Participants with the STin2 9/12 or 12/12 genotype had 4-fold higher odds of PSD compared with STin2 10/10 genotype carriers (odds ratio, 4.1; 95% confidence interval, 1.2-13.6). An association of rs25531 with PSD was not shown.
Conclusions The 5-HTTLPR and the STin2 VNTR, but not the rs25531, polymorphisms of SERT are associated with PSD in stroke survivors. This gives further evidence of a role of SERT polymorphisms in mediating resilience to biopsychosocial stress.
Author Affiliations: Departments of Psychiatry and Behavioral Sciences (Drs Kohen and Veith and Ms Navaja), Biostatistics (Dr Cain), Biobehavioral Nursing and Health Systems (Dr Mitchell and Ms Buzaitis), Neurology (Drs Becker and Tirschwell), and Psychosocial and Community Health (Dr Teri) and Office for Nursing Research (Dr Cain), University of Washington, Seattle; and Department of Veterans Affairs Puget Sound Health Care System, Seattle (Drs Kohen and Millard and Ms Navaja).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
RELATED ARTICLE
This Month in Archives of General Psychiatry
Arch Gen Psychiatry. 2008;65(11):1243.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Serotonergic and BDNF Genes Associated With Depression 1 Week and 1 Year After Mastectomy for Breast Cancer
Kim et al.
Psychosom. Med. 2012;74:8-15.
ABSTRACT
| FULL TEXT
Searching for the Noninvasive Biomarker Holy Grail: Are Urine Proteomics the Answer?
Voss et al.
Biol Res Nurs 2011;13:235-242.
ABSTRACT
Response to Psychosocial Treatment in Poststroke Depression Is Associated With Serotonin Transporter Polymorphisms
Kohen et al.
Stroke 2011;42:2068-2070.
ABSTRACT
| FULL TEXT
Role of mother's genes and environment in postpartum depression
Mitchell et al.
Proc. Natl. Acad. Sci. USA 2011;108:8189-8193.
ABSTRACT
| FULL TEXT
The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-analysis Revisited: Evidence of Genetic Moderation
Karg et al.
Arch Gen Psychiatry 2011;68:444-454.
ABSTRACT
| FULL TEXT
Serotonin Transporter Gene Polymorphism in Chinese Patients With Poststroke Depression: A Case-Control Study
Fang et al.
Stroke 2011;42:1461-1463.
ABSTRACT
| FULL TEXT
The Heritability of Postpartum Depression
Corwin et al.
Biol Res Nurs 2010;12:73-83.
ABSTRACT
A Prospective Cohort Study Investigating Factors Associated With Depression During Medical Internship
Sen et al.
Arch Gen Psychiatry 2010;67:557-565.
ABSTRACT
| FULL TEXT
|
