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  Vol. 65 No. 5, May 2008 TABLE OF CONTENTS
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Eszopiclone Coadministered With Escitalopram in Patients With Insomnia and Comorbid Generalized Anxiety Disorder

Mark Pollack, MD; Gustavo Kinrys, MD; Andrew Krystal, MD; W. Vaughn McCall, MD, MS; Thomas Roth, PhD; Kendyl Schaefer, MS; Robert Rubens, MD, MBA; James Roach, MD; Holly Huang, MS; Ranga Krishnan, MD

Arch Gen Psychiatry. 2008;65(5):551-562.

Context  Insomnia and generalized anxiety disorder (GAD) are prevalent disorders that may coexist.

Objective  To determine the efficacy of eszopiclone combined with escitalopram oxalate in treating insomnia comorbid with GAD.

Design  Double-blind, randomized, placebo-controlled, parallel-group, add-on therapy 10-week study.

Setting  Multicenter outpatient study from July 2005 to April 2006.

Patients  Adults aged 18 to 64 years meeting DSM-IV-TR criteria for GAD and insomnia.

Interventions  Patients received 10 mg of escitalopram oxolate for 10 weeks and were randomized to also receive either 3 mg of eszopiclone (n = 294) or placebo (n = 301) nightly for 8 weeks. For the last 2 weeks, eszopiclone was replaced with a single-blind placebo.

Main Outcome Measures  Sleep, daytime functioning, psychiatric measures, and adverse events.

Results  Compared with treatment with placebo and escitalopram, treatment with eszopiclone and escitalopram resulted in significantly improved sleep and daytime functioning (P < .05), with no evidence of tolerance. Patients taking eszopiclone and escitalopram had greater improvements in total Hamilton Anxiety Scale (HAM-A) scores at each week (P < .05) and at weeks 4 through 10 with the insomnia item removed. Clinical Global Impressions (CGI) of Improvement scores were improved with eszopiclone and escitalopram at every point (P < .02), while CGI of Severity of Illness scores were not significantly different after week 1. The HAM-A response (63% vs 49%, respectively, P = .001) and remission (42% vs 36%, respectively, P = .09) rates at week 8 were higher in patients treated with eszopiclone and escitalopram than those treated with placebo and escitalopram, and median time to onset of anxiolytic response was significantly reduced (P ≤ .05). After eszopiclone discontinuation, there was no evidence of rebound insomnia, and while treatment differences in anxiety measures were maintained, differences in sleep outcomes were not. Overall adverse event rates were 77.6% with cotherapy and 67.9% with monotherapy. The most common adverse events with cotherapy were unpleasant taste, headache, dry mouth, and somnolence.

Conclusions  Coadministration of eszopiclone and escitalopram was well tolerated and associated with significantly improved sleep, daytime functioning, anxiety, and mood in patients with insomnia and GAD.

Trial Registration  clinicaltrials.gov Identifier: NCT00235508


Author Affiliations: Massachusetts General Hospital, Boston (Dr Pollack); Cambridge Health Alliance, Cambridge, Massachusetts, and Harvard Medical School, Boston (Dr Kinrys); Duke University Medical Center, Durham, North Carolina (Drs Krystal and Krishnan); Wake Forest University Health Sciences, Winston-Salem, North Carolina (Dr McCall); Henry Ford Sleep Disorders Center, Detroit, Michigan (Dr Roth); and Sepracor Inc, Marlborough, Massachusetts (Mss Schaefer and Huang and Drs Rubens and Roach).



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