This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (11)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Neurology  • Cognitive Disorders  • Dementias  • Depression  • Alert me on articles by topic  Social Bookmarking   What's this?

Integrating Clinical and Epidemiological Perspectives

Arch Gen Psychiatry. 1998;55:1082-1083.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE STUDY by Bassuk et al¹ adds to an expanding literature assessing whether depression is a risk factor for new-onset dementia or whether relationships are cross-sectional rather than predictive; the former would indicate depression as prodromal and the latter as a clinical concomitant disorder. In their analysis of prospective epidemiological data, Bassuk and colleagues found high scores (16) on the Center for Epidemiological Studies Depression Scale (CES-D)² to predict subsequent cognitive decline, but only in persons exhibiting mild baseline impairment. Thus, depression seemed to be an early feature of a progressive disorder but not a risk factor for incident dementia. The concomitant feature argument is strengthened by the close temporal association between achieving the CES-D cutoff and demonstration of cognitive decline.

CLINICAL STUDIES

Early studies of depression-dementia associations used clinical samples. Wells³ applied the concept of pseudodementia, developed by Kiloh,⁴ to describe patients with symptomatic but not objective evidence of disturbed . . . [Full Text of this Article]

EPIDEMIOLOGICAL STUDIES

IMPLICATIONS


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

APOE-{epsilon}4, Depressive Symptoms, and Cognitive Decline in Chinese Older Adults: Singapore Longitudinal Aging Studies
Niti et al.
J Gerontol A Biol Sci Med Sci 2009;64A:306-311.
ABSTRACT | FULL TEXT  

The Temporal Relationship Between Depression Symptoms and Cognitive Functioning in Older Medical Patients--Prospective or Concurrent?
Han et al.
Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2006;61:1319-1323.
ABSTRACT | FULL TEXT  

Depression as a Risk Factor for Alzheimer Disease: The MIRAGE Study
Green et al.
Arch Neurol 2003;60:753-759.
ABSTRACT | FULL TEXT  

Depression and risk of cognitive decline and Alzheimer's disease: Results of two prospective community-based studies in The Netherlands
GEERLINGS et al.
Br. J. Psychiatry 2000;176:568-575.
ABSTRACT | FULL TEXT