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Integrating Clinical and Epidemiological Perspectives

Arch Gen Psychiatry. 1998;55:1082-1083.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE STUDY by Bassuk et al¹ adds to an expanding literature assessing whether depression is a risk factor for new-onset dementia or whether relationships are cross-sectional rather than predictive; the former would indicate depression as prodromal and the latter as a clinical concomitant disorder. In their analysis of prospective epidemiological data, Bassuk and colleagues found high scores (16) on the Center for Epidemiological Studies Depression Scale (CES-D)² to predict subsequent cognitive decline, but only in persons exhibiting mild baseline impairment. Thus, depression seemed to be an early feature of a progressive disorder but not a risk factor for incident dementia. The concomitant feature argument is strengthened by the close temporal association between achieving the CES-D cutoff and demonstration of cognitive decline.

CLINICAL STUDIES

Early studies of depression-dementia associations used clinical samples. Wells³ applied the concept of pseudodementia, developed by Kiloh,⁴ to describe patients with symptomatic but not objective evidence of disturbed . . . [Full Text of this Article]

EPIDEMIOLOGICAL STUDIES

IMPLICATIONS


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