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Clozapine is the prototype atypical antipsychotic drug. The term atypical antipsychotic refers to drugs that do not cause catalepsy in animals, have a minor or no effect on plasma prolactin, do not cause extrapyramidal symptoms in humans, do not cause tardive dyskinesia, are effective in the treatment of negative symptoms, and may be effective in nonresponders to classical neuroleptics. We have previously demonstrated in positron emission tomography (PET) studies that clozapine is atypical also with regard to the degree of striatal D₂ dopamine receptor occupancy during clinical treatment. While all classical antipsychotic drugs occupied 70% to 90% of the striatal D₂ receptors, the D₂ occupancy during clozapine treatment was significantly lower (20%-67%).¹ The maximal D₂ occupancy during clinical treatment with clozapine at very high plasma concentrations was estimated to be about 60%.²

Olanzapine is a new antipsychotic that has been put forward as an atypical antipsychotic drug, based on preclinical . . . [Full Text of this Article]

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