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The Structure of Psychosis
Syndromes and Dimensions
Arch Gen Psychiatry. 1998;55:508-509.
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PSYCHIATRIC nosology has been too long the province of speculation and pronouncement, particularly in the area of psychotic disorders, where powerful empirical studies are rare.
WHAT WE DID
Our study1 began with a large epidemiological sample of treated patients with psychotic and affective illness studied an average of 15 years after onset. Based on personal interviews and review of hospital records, we blindly coded symptom and outcome data. We submitted these data to a latent class analysis (LCA): a statistical technique that attempted to explain the observed distribution of symptoms in these probands as resulting from a small number of discrete syndromes.2
In light of the comments by Crow,3 it is important to emphasize the difference between LCA and factor analysis. Factor analysis, like a psychometrican, groups questionnaire items into scales. Latent class analysis, like a nosologist, groups patients into diagnostic classes. Latent class analysis is an agnostic, statistical analog of the approach . . . [Full Text of this Article]
WHAT WE FOUND
DR CROW'S COMMENTS
CONCLUSIONS
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Kenneth S. Kendler, Laura M. Karkowski, and Dermot Walsh
Arch Gen Psychiatry. 1998;55(6):492-499.
ABSTRACT
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From Kraepelin to Kretschmer Leavened by Schneider: The Transition From Categories of Psychosis to Dimensions of Variation Intrinsic to Homo sapiens
Tim J. Crow
Arch Gen Psychiatry. 1998;55(6):502-504.
EXTRACT
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