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Arch Gen Psychiatry. 1998;55:692-693.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

IN THIS issue of the ARCHIVES, Hall and her colleagues¹ present data indicating that nortriptyline hydrochloride, a tricyclic antidepressant, increases smoking abstinence rates. Using antidepressant drugs as aids to smoking cessation stems from the 1988 observation that cigarette smoking is associated with a history of major depression and that a history of depression predicts smoking cessation failure.² These observations have been replicated on numerous occasions and it is now clear that nicotine withdrawal can provoke depression in smokers with a history of depression.³ These observations led a number of individual investigators as well as pharmaceutical manufacturers to hypothesize that antidepressant compounds might aid smoking cessation. However, the trials that tested this hypothesis produced unanticipated results.

The expectation was that if antidepressants aided smoking cessation, that effect would be true for all antidepressants, and if one class of antidepressants seemed most likely to be useful, it was the selective serotonin reuptake . . . [Full Text of this Article]

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