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In a recent issue of the ARCHIVES, Ross et al¹ have confirmed that phospholipase A₂ (PLA₂) levels are elevated in the serum of schizophrenic patients, demonstrated that the elevation is restricted to a novel calcium-independent form of this enzyme class,² and suggested why some previous assay methods have failed to detect elevated PLA₂levels. This article establishes elevated PLA₂ levels as one component of a biochemical phenotype characteristic of schizophrenia, and thus provides a potentially important clue for further research—regardless of whether the elevated PLA₂ proves to represent a cause or a consequence of schizophrenia, and regardless of whether it proves to be linked to the underlying disease process or to treatment with neuroleptics.

The article by Ross et al is the first to discuss calcium-independent PLA₂ in the context of schizophrenia, and implies that these 2 fields of inquiry are linked in some biologically relevant manner. However, it . . . [Full Text of this Article]