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Randomized Controlled Trials in Archives of General Psychiatry (1959-1995): A Prevalence Study
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A single randomized controlled trial (RCT) is often not powerful enough to guide practice. Systematic reviews, compiled from every relevant trial, frequently give more confident directions for practice. The Cochrane Collaboration1 produces, electronically maintains, and disseminates systematic reviews of the effects of health care interventions. However, because electronic databases are an inadequate source for trials, hand-searching of relevant literature is often undertaken.2
Every page of the ARCHIVES (1959-1995) was reliably hand searched. Electronic records were created and details regarding country of origin, participants, interventions, outcomes, funding, size and length of trial, and quality of reporting of randomization were recorded.
A total of 621 RCTs or likely RCTs were identified. Four hundred eighty-three (77.8%) at least stated that participants had been randomized; 27 of these were not included in MEDLINE. The majority of first authors of trials (92.9%) were from the United States and this proportion had not changed between the . . . [Full Text of this Article]
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