This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (21)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Schizophrenia  • Alert me on articles by topic

Timing Is of the Essence

Arch Gen Psychiatry. 1999;56:1007-1008.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

WHAT TYPES of neurocognitive deficits do patients with schizophrenia have? The list of seemingly unrelated neurocognitive deficits is rather long and leaves one yearning for parsimony. After hearing about problems with vigilance, secondary memory, sensory gating, problem solving, psychomotor abilities, and verbal fluency, one wonders about a simpler way to view the problem. Surely, when a complex system such as cognitive processing breaks down in schizophrenia, it must do so in a small number of basic ways that generate a variety of cognitive performance deficits. But how do we conceptualize these basic deficits?

For many years, the search was on for a region of the brain that could explain the variety of deficits in schizophrenia. As the questions became more influenced by neuroscience, the search shifted from key regions to key neural circuits. However, an anatomy-focused approach may be too limiting for an explanation of how a variety of neurocognitive . . . [Full Text of this Article]

RELATED ARTICLE

Gamma Frequency–Range Abnormalities to Auditory Stimulation in Schizophrenia
Jun Soo Kwon, Brian F. O'Donnell, Gene V. Wallenstein, Robert W. Greene, Yoshio Hirayasu, Paul G. Nestor, Michael E. Hasselmo, Geoffrey F. Potts, Martha E. Shenton, and Robert W. McCarley
Arch Gen Psychiatry. 1999;56(11):1001-1005.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Reduced Evoked Gamma Oscillations in the Frontal Cortex in Schizophrenia Patients: A TMS/EEG Study
Ferrarelli et al.
Am. J. Psychiatry 2008;165:996-1005.
ABSTRACT | FULL TEXT  

Neuregulin-1 Modulates Hippocampal Gamma Oscillations: Implications for Schizophrenia
Fisahn et al.
Cereb Cortex 2008;0:bhn107v1-bhn107.
ABSTRACT | FULL TEXT  

Application of Electroencephalography to the Study of Cognitive and Brain Functions in Schizophrenia
van der Stelt and Belger
Schizophr Bull 2007;33:955-970.
ABSTRACT | FULL TEXT  

Event-Related Gamma Activity in Schizophrenia Patients During a Visual Backward-Masking Task
Wynn et al.
Am. J. Psychiatry 2005;162:2330-2336.
ABSTRACT | FULL TEXT  

Applying New Approaches From Cognitive Neuroscience to Enhance Drug Development for the Treatment of Impaired Cognition in Schizophrenia
Carter
Schizophr Bull 2005;31:810-815.
ABSTRACT | FULL TEXT  

Macroscopic fast neuronal oscillations and synchrony in schizophrenia
van der Stelt et al.
Proc. Natl. Acad. Sci. USA 2004;101:17567-17568.
FULL TEXT