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Omega-3 Fatty Acids—The Missing Link?
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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In their excellent review on the relationship of depression to cardiovascular disease, Musselman et al1 conclude that major depression and its associated symptoms constitute a major risk factor for both the development of cardiovascular disease and death after an index myocardial infarction. In their discussion on potential pathophysiological mechanisms underlying this relationship, however, they do not mention one factor which we believe is crucial to this topic—a possible deficiency of omega-3 fatty acids.
In numerous studies, including prospective cohort studies,2 case-control studies,3 and intervention trials4—omega-3 fatty acids have been shown to reduce the risk of primary cardiac arrest/sudden cardiac death, presumably owing to their antiarrhythmic properties. A prospective double-blind, placebo-controlled trial of omega-3 fatty acids observed a notable reduction of moderate to low-grade ventricular premature complexes in patients with frequent ventricular arrhythmias.5 Furthermore, a high arachidonic acid (omega-6)–docosahexaenoic acid ratio (omega-3) has been reported in the heart muscle of . . . [Full Text of this Article]
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