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A Promising but Untested Treatment

Arch Gen Psychiatry. 1999;56:413-414.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

IN THIS issue of the ARCHIVES, Stoll and colleagues¹ report innovative preliminary data on the putative mood-stabilizing properties of a fish oil containing 3 fatty acids in the treatment of bipolar disorder (types I and II).² Acting on the assumption that overactive cell-signaling pathways may be involved in the pathophysiological characteristics of bipolar disorder^3-4 and the finding that 3 fatty acids are associated with a general dampening of signal transduction pathways associated with phosphatidylinositol, arachidonic acid, and other systems,⁵ Stoll et al performed a controlled study to explore the mood-stabilizing effects of high-dose 3 fatty acids.

In this study, subjects were randomly assigned to parallel groups after stratifying for sex, recent lithium use, and a history of rapid cycling. The primary outcome measure was the duration of time to exit the blinded phase of the study for treatment of an emerging mood episode; the decision to end treatment was at . . . [Full Text of this Article]

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