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A Measured Milestone in Schizophrenia Research
Arch Gen Psychiatry. 2000;57:74-75.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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THE PAST 2 decades have witnessed a resurgence of interest in identifying the structural underpinnings of schizophrenia. Neuroimaging studies have shown that in schizophrenic subjects the brain as a whole and the frontal cortex in particular are smaller than in normal subjects.1-3 A wealth of data has established that prefrontal cortical dysfunction—for example, impairments in working memory, abstract thinking, attention, and language coherency—are prominent symptoms of schizophrenia.4 Yet just what is missing in the schizophrenic prefrontal cortex to account for these deficits has been hard to pinpoint. There are no obvious signs of pathology, neuronal loss, or gliosis in the prefrontal cortex in schizophrenic patients. Perhaps because of the subtle nature of the structural deficit, progress in identifying an anatomical substrate for schizophrenia has come only with the application of quantitative methods. Recent stereologic analyses of the prefrontal cortex have begun to home in on the deficit, revealing the presence . . . [Full Text of this Article]
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