This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (60)  • Contact me when this article is cited  Related Content  • Similar articles in this journal

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The discovery of lithium's carbonate efficacy as an antimanic agent revolutionized the treatment of patients with bipolar disorder, but despite its remarkable effect on the lives of millions,¹ the biochemical basis for its antimanic effects remains to be elucidated.² In recent years, considerable progress has been made in the identification of signal transduction pathways as targets for the action of long-term lithium use.^2-3 Regulation of signal transduction affects the intracellular signal generated by multiple neurotransmitter systems. These affects are attractive candidates as mediators of lithium's therapeutic effects, since the behavioral and physiological manifestations of mania are complex, including a disruption of sleep and motor, cognitive, and psychological function, and are likely mediated by a network of interconnected neurotransmitter pathways. It is particularly noteworthy that when administered long-term (days to weeks), the 2 clinically efficacious^4-6 (but structurally dissimilar) antimanic agents, lithium and valproate, bring about similar isozyme-selective reductions in the levels . . . [Full Text of this Article]

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Clinical Trials in Bipolar Mania: Implications in Study Design and Drug Development
Tohen
Arch Gen Psychiatry 2008;65:252-253.
FULL TEXT  

Protein Kinase C Inhibition in the Treatment of Mania: A Double-blind, Placebo-Controlled Trial of Tamoxifen
Yildiz et al.
Arch Gen Psychiatry 2008;65:255-263.
ABSTRACT | FULL TEXT  

Modelling facets of mania - new directions related to the notion of endophenotypes
Einat
J Psychopharmacol 2006;20:714-722.
ABSTRACT  

Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene.
Haeger et al.
J. Neurosci. 2006;26:4908-4916.
ABSTRACT | FULL TEXT  

Hippocampal Volume and First Major Depressive Episode After Cancer Diagnosis in Breast Cancer Survivors
Inagaki et al.
Am. J. Psychiatry 2004;161:2263-2270.
ABSTRACT | FULL TEXT  

MOLECULAR EFFECTS of lithium
Quiroz et al.
Mol. Interv. 2004;4:259-272.
ABSTRACT | FULL TEXT  

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice
Etcheberrigaray et al.
Proc. Natl. Acad. Sci. USA 2004;101:11141-11146.
ABSTRACT | FULL TEXT  

Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilisers
MANJI et al.
Br. J. Psychiatry 2001;178 :s107-s119.
ABSTRACT | FULL TEXT