This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (19)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Women's Health  • Women's Health, Other  • Depression  • Alert me on articles by topic

Arch Gen Psychiatry. 2000;57:1163-1164.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A 2-FOLD higher risk for depression among women compared with men has been consistently documented worldwide.^1-5 The epidemiological findings that the sex differences are manifested during reproductive age and actually disappear during the menopausal stage⁴ suggest an important involvement of reproduction-related processes, especially the hypothalamo-pituitary-gonadal axis in the pathobiology of depression in women. The focus of the search for the culprit has been on peripheral levels of the gonadal hormones—especially estrogen. A more comprehensive approach includes plasma levels of the pituitary hormones follicle-stimulating hormone and luteinizing hormone and their pulsatility, reflecting the hypothalamus' effect on the system and indicating the system's integrity.

As Young and colleagues conclude in this issue of the ARCHIVES, "Our study found generally normal reproductive function in women with depression in both the follicular and luteal phase compared with control women matched by age and menstrual cycle day." Their data are in accord with previous reports.^6-10 . . . [Full Text of this Article]

RELATED ARTICLE

Alteration in the Hypothalamic-Pituitary-Ovarian Axis in Depressed Women
Elizabeth A. Young, A. Rees Midgley, Nichole E. Carlson, and Morton B. Brown
Arch Gen Psychiatry. 2000;57(12):1157-1162.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Evidence of an Association Between the Vasopressin V1b Receptor Gene (AVPR1B) and Childhood-Onset Mood Disorders
Dempster et al.
Arch Gen Psychiatry 2007;64:1189-1195.
ABSTRACT | FULL TEXT  

Associations of hormones and menopausal status with depressed mood in women with no history of depression.
Freeman et al.
Arch Gen Psychiatry 2006;63:375-382.
ABSTRACT | FULL TEXT  

Hormones and Menopausal Status as Predictors of Depression in Women in Transition to Menopause
Freeman et al.
Arch Gen Psychiatry 2004;61:62-70.
ABSTRACT | FULL TEXT  

Depression and Its Influence on Reproductive Endocrine and Menstrual Cycle Markers Associated With Perimenopause: The Harvard Study of Moods and Cycles
Harlow et al.
Arch Gen Psychiatry 2003;60:29-36.
ABSTRACT | FULL TEXT  

Rhythmicity in the Regulation of Luteinizing Hormone Release
Meller and Grambsch
Arch Gen Psychiatry 2002;59:566-567.
FULL TEXT