This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (2)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Depression  • Suicide  • Alert me on articles by topic  Social Bookmarking   What's this?

Arch Gen Psychiatry. 2000;57:739-740.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE ARTICLE by Mann and coworkers¹ demonstrates, with a respectably large sample size, the association of major depression and suicide with low levels of serotonin transporter (5-HTT) binding in the prefrontal cortex. This extends these authors' previous demonstration of low levels of 5-HTT binding in prefrontal cortex from those who had committed suicide reported in a smaller sample size.² Furthermore, the authors demonstrate, for the first time, that the anatomy of 5-HTT loss in the prefrontal cortex of subjects with major depression is more widespread than that found in those who commit suicide. The recent identification of a polymorphism in the promoter region of the human 5-HTT gene³ (5-HTTLPR) and the demonstration that the short promoter form has lower activity⁴ led these authors to logically examine the possible association of reduced 5-HTT in depression and suicide with the short-form (less active) 5-HTTLPR. As cited in their article, there is . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?