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Arch Gen Psychiatry. 2000;57:739-740.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE ARTICLE by Mann and coworkers¹ demonstrates, with a respectably large sample size, the association of major depression and suicide with low levels of serotonin transporter (5-HTT) binding in the prefrontal cortex. This extends these authors' previous demonstration of low levels of 5-HTT binding in prefrontal cortex from those who had committed suicide reported in a smaller sample size.² Furthermore, the authors demonstrate, for the first time, that the anatomy of 5-HTT loss in the prefrontal cortex of subjects with major depression is more widespread than that found in those who commit suicide. The recent identification of a polymorphism in the promoter region of the human 5-HTT gene³ (5-HTTLPR) and the demonstration that the short promoter form has lower activity⁴ led these authors to logically examine the possible association of reduced 5-HTT in depression and suicide with the short-form (less active) 5-HTTLPR. As cited in their article, there is . . . [Full Text of this Article]

RELATED ARTICLE

A Serotonin Transporter Gene Promoter Polymorphism (5-HTTLPR) and Prefrontal Cortical Binding in Major Depression and Suicide
J. John Mann, Yung-yu Huang, Mark D. Underwood, Suham A. Kassir, Sara Oppenheim, Thomas M. Kelly, Andrew J. Dwork, and Victoria Arango
Arch Gen Psychiatry. 2000;57(8):729-738.
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