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Internal Night
Arch Gen Psychiatry. 2001;58:1115-1116.
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IF WE KNEW the physiological cue for the annual change that triggers
winter depression, the syndrome of seasonal affective disorder (SAD) would
be validated, and there would be a rational basis for designing therapeutic
interventions. The depressogenic effect of long winter nights coupled with
the antidepressant effect of morning light therapy make for a plausible story
line. In this issue of the ARCHIVES, Wehr et al1
at the National Institute of Mental Health (NIMH) report that the melatonin
secretion profile, an internal correlate of night length controlled by the
hypothalamic biological clock, is linked to emergence and remission of the
depression. By aggregating the largest sample size ever for such a study (55
patients and matched controls), they are able to derive virtually noise-free
melatonin curves with a set of discrete anchor points: secretion onset and
offset as well as final daytime clearance of the hormone from blood circulation.
ABSOLUTE NIGHT LENGTH VS SEASONAL CHANGE
Patients . . . [Full Text of this Article]
LIGHT THERAPY VS NATURAL LIGHT
LARKS VS OWLS
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RELATED ARTICLE
A Circadian Signal of Change of Season in Patients With Seasonal Affective Disorder
Thomas A. Wehr, Wallace C. Duncan, Jr, Leo Sher, Daniel Aeschbach, Paul J. Schwartz, Erick H. Turner, Teodor T. Postolache, and Norman E. Rosenthal
Arch Gen Psychiatry. 2001;58(12):1108-1114.
ABSTRACT
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