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Recently, Raine et al¹ reported significant reduction of prefrontal gray matter and reduced skin-conductance responses to aversive stimuli in patients with antisocial personality disorder (APD) and high rates of violence perpetration (as compared with healthy men or men with other psychiatric disorders).¹ In his commentary to this article, Damasio pointed out that it is important to test the specificity of this finding.² Similar and highly significant reductions of cortical gray matter that could not be detected on visual inspection of the magnetic resonance imaging scan have been reported in patients with intermittent explosive disorder, and epilepsy without any other psychiatric disorder.³ Interestingly, this finding was clearly lateralized to the left dorsolateral prefrontal cortex. Unfortunately, Raine et al¹ did not comment on whether their interesting finding was lateralized or whether it was more pronounced in the dorsolateral, orbiofrontol, or frontomedial prefrontal cortex. Using a voxel-based analysis following the study by Wright . . . [Full Text of this Article]

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Ventromedial Prefrontal Cortex and Amygdala Dysfunction During an Anger Induction Positron Emission Tomography Study in Patients With Major Depressive Disorder With Anger Attacks
Dougherty et al.
Arch Gen Psychiatry 2004;61:795-804.
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