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The Mood-Lowering Effect of Tryptophan Depletion: Possible Explanation for Discrepant Findings
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Tryptophan depletion (TD) is an experimental procedure for studying
brain serotonin function. The mood-lowering effect of TD has been demonstrated
in formerly depressed patients treated with selective serotonin reuptake inhibitors
(SSRIs) or monoamine oxidase inhibitors1
and in medication-free women with a history of recurrent depressive episodes.2 Typically, a little more than half of the patients
experience the effect. It is not exactly clear why some patients experience
the effect while others do not. Several studies have recently found that the
effect may be less consistent than previously thought. Moore et al3 observed no effect on mood in fully remitted patients
medicated with SSRIs. In a study4 of patients
who had responded to treatment with citalopram, only 5 of 12 patients relapsed,
and the effect seemed to be clinically significant in only 1 patient. In a
third study,5 only 33% of 21 patients experienced
a relapse. Moore et al3 suggest that . . . [Full Text of this Article]
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