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Arch Gen Psychiatry. 2001;58:229-230.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

IN THIS issue, Penninx et al¹ report the results of a longitudinal study of depression as a risk factor for cardiac mortality in elderly, community-dwelling residents of Amsterdam, the Netherlands. This study joins a growing number of methodologically sound investigations showing that depression increases the risk of cardiac mortality, yet some fundamental questions remain about depression as a cardiovascular risk factor. Their study addresses 2 such questions that have both mechanistic and clinical relevance.

The first is whether only individuals with major depression are at increased risk for mortality, or if the risk extends to patients with less severe depression. If only individuals with major depressive disorder are at increased risk, we should be searching for mechanisms that are present in major depression but not in milder depressive syndromes. If milder depression also increases the risk of mortality, we should search instead for factors that are associated with depression along . . . [Full Text of this Article]

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Depression and Cardiac Mortality: Results From a Community-Based Longitudinal Study
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Arch Gen Psychiatry. 2001;58(3):221-227.
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