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Harlow et al¹ recently published data from a study describing prevalence and predictors of depression in older premenopausal women. The study describes a significant rate (22.4%) of current depressive symptoms (defined as Center for Epidemiologic Studies Depression Scale [CES-D]² score >16) in a cross-sectional population-based study. It also describes a significant association between past or current depression and a higher risk for depressive symptoms and premenstrual complaints, particularly among women with significant premenstrual functioning impairment.

In a recent study,^{3, 4} we noted a high prevalence (49.5%) of psychiatric morbidity (Self-Rating Questionnaire score [SRQ-20]⁵ >7) among 101 endocrinologically confirmed perimenopausal women attending a menopause clinic (age, 40-58 years; menstrual irregularity, >6 months; amenorrhea, <1 year; follicle-stimulating hormone levels, >20 IU/L). In addition, all women experiencing significant psychiatric symptoms were further assessed with the Mood Module from the Primary Care Evaluation of Mental Disorders (PRIME-MD) questionnaire⁶ to investigate depressive disorders according to DSM-IV⁷ . . . [Full Text of this Article]

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