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Cognitive Impairment With Chronic Disease in Depression and Mortality
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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I read with interest the study on the relationship between depression
and mortality in the October issue of the ARCHIVES.1
Studies of mental illness in older adults are urgently needed due to the aging
of our population. The inclusion in this study of explanatory variables measuring
the health and health behaviors of the participants made the study just that
much more valuable.
I wondered whether a misspecification bias might have been introduced
into the study when the investigators did not include cognitive impairment
along with chronic diseases as a possible confounding variable. The inclusion
of stroke and peripheral atherosclerosis would account for some cases of cognitive
impairment. However, dementing illnesses such as Alzheimer disease may have
contributed to the mortality rate as well. Also, according to the terminal
drop hypothesis, a rapid diminishment of cognitive functioning marks the 5
years preceding death in elderly people.2
Inclusion of cognitive functioning as . . . [Full Text of this Article]
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