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Leptin as a Possible Modulator of Craving for Alcohol
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Whereas the psychological construct and pathophysiological basis of
craving for alcohol, a major risk for relapse in alcoholism, has been intensively
evaluated in recent years, no measurable biological correlate exists.1 Neurobiological and psychological similarities
between craving and appetite are well established since both are known to
be influenced by the mesolimbic brain reward system and its endorphinergic
inputs.2 Recently, leptin, the protein product
of the obesity gene, was proposed to be a signal responsible for linking adipose
stores with hypothalamic centers regulating energy homeostasis and body weight.3 In addition, leptin has been shown to alter the
gene expression of corticotropin-releasing hormone and pro-opiomelanocortin
in the hypothalamus, suggesting a role both in regulating the stress hormone
axis and possibly in the endorphinergic modulation of the reward system.4 Leptin mutually interacts with other neuroendocrine
systems involved in the regulation of appetite such as NPY (neuropeptide Y)3 or the newly discovered hypothalamic peptide . . . [Full Text of this Article]
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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INCREASED FASTING PLASMA GHRELIN LEVELS DURING ALCOHOL ABSTINENCE
KIM et al.
Alcohol Alcohol 2005;40:76-79.
ABSTRACT
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LEPTIN LEVELS OF ALCOHOL ABSTAINERS AND DETOXIFICATION PATIENTS ARE NOT DIFFERENT
Wurst et al.
Alcohol Alcohol 2003;38:364-368.
ABSTRACT
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ALCOHOL INTAKE, TUMOUR NECROSIS FACTOR-{alpha}, LEPTIN AND CRAVING: FACTORS OF A POSSIBLY VICIOUS CIRCLE?
Kiefer et al.
Alcohol Alcohol 2002;37:401-404.
ABSTRACT
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