You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 58 No. 7, July 2001 TABLE OF CONTENTS
  Archives
  •  Online Features
  Commentary
 This Article
 •Full text
 •PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on ISI (9)
 •Contact me when this article is cited
 Related Content
 •Related articles
 •Similar articles in this journal
 Topic Collections
 •Depression
 •Psychotherapy
 •Alert me on articles by topic
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati
What's this?

Functional Brain Circuits in Major Depression and Remission

Arch Gen Psychiatry. 2001;58:649-650.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THROUGHOUT the past 20 years, findings from studies of functional brain imaging have coalesced in the identification of regions of abnormal functional activity during major depressive episodes (MDE).1-5 In studies performed during the resting state (no physiological or cognitive challenge), patients with MDE typically show reduced activity in the dorsolateral prefrontal cortex. At least 15 studies have found covariation between the magnitude of this reduction (or that of larger prefrontal areas) and the magnitude of depression severity,6-8 with the suggestion that reduced dorsolateral prefrontal cortex activity is tied to psychomotor retardation or cognitive disturbance.9-10 In contrast, the ventral prefrontal cortex has been found to show increased activity in some studies,4 with the exception that an area ventral to the genu of the corpus callosum may be subject to perfusion and metabolic reduction, which has been linked to neuronal loss.11 Abnormal functional activity has been observed in several studies of the . . . [Full Text of this Article]



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati     What's this?

RELATED ARTICLES

Regional Brain Metabolic Changes in Patients With Major Depression Treated With Either Paroxetine or Interpersonal Therapy: Preliminary Findings
Arthur L. Brody, Sanjaya Saxena, Paula Stoessel, Laurie A. Gillies, Lynn A. Fairbanks, Shervin Alborzian, Michael E. Phelps, Sung-Cheng Huang, Hsiao-Ming Wu, Matthew L. Ho, Mai K. Ho, Scott C. Au, Karron Maidment, and Lewis R. Baxter, Jr
Arch Gen Psychiatry. 2001;58(7):631-640.
ABSTRACT | FULL TEXT  

Brain Blood Flow Changes in Depressed Patients Treated With Interpersonal Psychotherapy or Venlafaxine Hydrochloride: Preliminary Findings
Stephen D. Martin, Elizabeth Martin, Santoch S. Rai, Mark A. Richardson, and Robert Royall
Arch Gen Psychiatry. 2001;58(7):641-648.
ABSTRACT | FULL TEXT  

Neuroimaging Profiles and the Differential Therapies of Depression
Michael E. Thase
Arch Gen Psychiatry. 2001;58(7):651-653.
EXTRACT | FULL TEXT  


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

High-Dimensional Mapping of the Hippocampus in Depression
Posener et al.
Am. J. Psychiatry 2003;160:83-89.
ABSTRACT | FULL TEXT  

Functional Neuroanatomy of Remission from Depression
JWatch Psychiatry 2001;2001:3-3.
FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 2001 American Medical Association. All Rights Reserved.