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Arch Gen Psychiatry. 2001;58:651-653.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE ARTICLES by Brody et al¹ and Martin et al,² published in this issue of the ARCHIVES, provide intriguing, albeit preliminary, new data on the functional neuroanatomy of depression. Using single-photon emission computed tomography (SPECT)² and ¹⁸F-fluorodeoxyglucose positron emission tomography (PET)¹ neuroimaging methods, outpatients with major depressive disorder were studied before and after treatment. What distinguishes these reports from earlier neuroimaging investigations using pretreatment and posttreatment designs is that both studies compared the effects of pharmacotherapy with those of interpersonal psychotherapy (IPT), one of the better studied psychosocial treatments of depression. The report of Brody et al¹ is further distinguished by inclusion of a healthy control group, also studied at 2 time points. Results indicated that both treatments were associated with increased blood flow to the left temporal¹ or right basal ganglia² regions. Moreover, in the study of Brody et al¹ both IPT and paroxetine treatment normalized metabolism in the . . . [Full Text of this Article]

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